General
Preferred name
PROCARBAZINE
Synonyms
PROCARBAZINE HYDROCHLORIDE ()
Matulane ()
PCB hydrochloride ()
Ibenzmethyzine hydrochloride ()
p-(N'-methylhydrazinomethyl)-N-isopropylbenzamide hydrochloride ()
MBH ()
Natulan ()
Nathulane ()
Natunalar ()
Procarbazine HCl ()
Procarbazine (hydrochloride) ()
Procarbazine HCl ()
NSC-77213 HCl ()
RO-4-6467 ()
RO-4-6467 FREE BASE ()
Procarbacine ()
RO 4-646711 ()
NCI-C-01810 ()
NSC-77213 ()
NCI-C 01810 ()
RO-4-6467 HYDROCHLORIDE ()
Ro-46467/1 ()
Procarbazini hydrochloridum ()
P&D ID
PD001685
CAS
671-16-9
366-70-1
Tags
prodrug
natural product
drug
available
Approved by
FDA
First approval
1969
Drug Status
investigational
approved
Drug indication
Antineoplastic
Hodgkin lymphoma
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Procarbazine is a DNA alkylating agent. (GtoPdb)
DESCRIPTION inducer of DNA damage (Informer Set)
DESCRIPTION Procarbazine Hydrochloride is an alkylating agent, with anticancer activity. (BOC Sciences Bioactive Compounds)
Compound Sets
25
BOC Sciences Bioactive Compounds
procarbazine-hydrochloride-cas-366-70-1-item-84-465336
Cayman Chemical Bioactives
16133
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL1321
CHEMBL1200410
ChEMBL Drugs
CHEMBL1321
CHEMBL1200410
Drug Repurposing Hub
DrugBank
DB01168
DrugBank Approved Drugs
DB01168
DrugCentral
2272
DrugCentral Approved Drugs
2272
DrugMAP
DMIK367
DrugMAP Approved Drugs
DMIK367
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
7278
Informer Set
28183
MedChem Express Bioactive Compound Library
HY-13733
NCATS Inxight Approved Drugs
35S93Y190K
NIH Approved Oncology Drugs
551000
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
procarbazine-hydrochloride-matulane
The Spectrum Collection
External IDs
62
Properties
(calculated by RDKit )
Molecular Weight
221.15
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
1
Aromatic Ring Count
1
cLogP
1.05
TPSA
53.16
Fraction CSP3
0.42
Chiral centers
0.0
Largest ring
6.0
QED
0.65
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Compound status
FDA
MOA
DNA alkylator
DNA/RNA Synthesis inhibitor
monoamine oxidase inhibitor
Target
DNA
DNA alkylator/crosslinker
DNA/RNA Synthesis
Indication
Hodgkin's lymphoma
Therapeutic Class
Anticancer Agents
Pathway
Cell Cycle/DNA Damage
Source data