General
Preferred name
SERATRODAST
Synonyms
AA 2414 ()
ABT-001 ()
Seratrodast(AA-2414) ()
AA-2414 ()
ABBOTT 73001 ()
ABBOTT-73001 ()
BRONICA ()
A-73001 ()
NSC-759640 ()
P&D ID
PD001678
CAS
112665-43-7
103186-19-2
103185-78-0
Tags
available
drug
Drug indication
Airway obstruction
Allergic asthma
Drug Status
approved
experimental
Max Phase
4.0
First approval
1995
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Seratrodast (AA 2414), an orally active antiasthmatic agent, is a thromboxane A2 receptor (TP) antagonist and ferroptosis inhibitor. Seratrodast reduces lipid ROS production, modulates the systemic xc-/GSH/GPX4 axis, and inhibits JNK phosphorylation and p53 expression. Seratrodast exhibits anti-asthmatic and anti-epileptic activity[1][2][3].
PRICE 35
DESCRIPTION Seratrodast is a potent and selective thromboxane A2 receptor (TP) antagonist used primarily in the treatment of asthma. (BOC Sciences Bioactive Compounds)
DESCRIPTION Seratrodast (ABT-001) (INN), a thromboxane A2 (TXA2) receptor (TP receptor) antagonist, is mainly used in the therapy of asthma. It was the first TP receptor antagonist developed as an anti-asthmatic drug and attained marketing qualification in Japan in 1997. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
2
Compound Sets
20
Axon Medchem Screening Library
1447
BOC Sciences Bioactive Compounds
seratrodast-cas-112665-43-7-item-84-54770
Cayman Chemical Bioactives
9002014
ChEMBL Approved Drugs
CHEMBL70972
ChEMBL Drugs
CHEMBL70972
DrugBank
DB06739
DrugCentral
2432
DrugCentral Approved Drugs
2432
DrugMAP
DMPNTDL
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
EOS100714
EUbOPEN Chemogenomics Library
EUB0000800
Mcule NIBR MoA Box Subset
MCULE-7829476338
MedChem Express Bioactive Compound Library
HY-B0774
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
seratrodast
TargetMol Bioactive Compound Library
T0212
The Spectrum Collection
External IDs
22
Properties
(calculated by RDKit )
Molecular Weight
354.18
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
8
Ring Count
2
Aromatic Ring Count
1
cLogP
4.61
TPSA
71.44
Fraction CSP3
0.41
Chiral centers
1.0
Largest ring
6.0
QED
0.55
Structural alerts
1
quinone_A(370)
[!#6&!#1]=[#6]1[#6]=,:[#6][#6](=[!#6&!#1])[#6]=,:[#6]1
PAINS Family A
Related compounds
Custom attributes
(extracted from source data)
Target
COX
Prostaglandin Receptor
TXA2R
Thromboxane A2 antagonist
Ferroptosis
JNK
MDM-2/p53
Reactive Oxygen Species (ROS)
Reactive Oxygen Species
MOA
COX inhibitor
PPAR antagonist
Prostanoid TP Antagonists
Member status
member
Pathway
DNA Damage/DNA Repair
GPCR/G protein
Immunology/Inflammation
Metabolism
Neuroscience
Apoptosis
MAPK/ERK Pathway
Metabolic Enzyme/Protease
NF-κB
NF-¦ÊB
Recommended Cell Concentration
10 uM
Source data