General
Preferred name
SERATRODAST
Synonyms
AA 2414 ()
ABT-001 ()
Seratrodast(AA-2414) ()
AA-2414 ()
NSC-759640 ()
BRONICA ()
ABBOTT 73001 ()
A-73001 ()
ABBOTT-73001 ()
P&D ID
PD001678
CAS
112665-43-7
103186-19-2
103185-78-0
Tags
available
drug
Drug indication
Anti-Asthmatic (thromboxane receptor antagonist)
Anti-Inflammatory (nonantihistaminic)
Allergic asthma
Drug Status
approved
experimental
Max Phase
4.0
First approval
1995
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Seratrodast is a potent and selective thromboxane A2 receptor (TP) antagonist used primarily in the treatment of asthma.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
20
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
EUbOPEN Chemogenomics Library
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
22
Molecular Weight
354.18
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
8
Ring Count
2
Aromatic Ring Count
1
cLogP
4.61
TPSA
71.44
Fraction CSP3
0.41
Chiral centers
1.0
Largest ring
6.0
QED
0.55
Structural alerts
1
quinone_A(370)
[!#6&!#1]=[#6]-1-[#6]=,:[#6]-[#6](=[!#6&!#1])-[#6]=,:[#6]-1
PAINS Family A
Related compounds
Custom attributes
(extracted from source data)
Pathway
Immunology/Inflammation
Metabolism
Neuroscience
DNA Damage/DNA Repair
Apoptosis
GPCR/G protein
MAPK/ERK Pathway
Metabolic Enzyme/Protease
NF-κB
Target
COX
TXA2R
Thromboxane A2 antagonist
Ferroptosis
JNK
MDM-2/p53
Prostaglandin Receptor
Reactive Oxygen Species
MOA
COX inhibitor
PPAR antagonist
Prostanoid TP Antagonists
Member status
member
Recommended Cell Concentration
None
Source data
