General
Preferred name
ITOPRIDE
Synonyms
ITOPRIDE HYDROCHLORIDE ()
HSR803 ()
Ganaton ()
ITOPRIDE HCl ()
Itopride (hydrochloride) ()
Ganaton, HSR803 ()
Itopride hydrochloride ()
Itoprida ()
NSC-759643 ()
P&D ID
PD001662
CAS
122898-67-3
122892-31-3
Tags
available
drug
Drug Status
approved
investigational
Max Phase
3.0
Drug indication
Irritable bowel syndrome
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA
Itopride has anticholinesterase (AchE) activity as well as dopamine D2 receptor antagonistic activity. It is well established that M3 receptors exist on the smooth muscle layer throughout the gut and acetylcholine (ACh) released from enteric nerve endings stimulates the contraction of smooth muscle through M3 receptors. The enzyme AChE hydrolyses the released ACh, inactivates it and thus inhibits the gastric motility leading to various digestive disorders. Besides ACh, dopamine is present in significant amounts in the gastrointestinal tract and has several inhibitory effects on gastrointestinal motility, including reduction of lower esophageal sphincter and intragastric pressure. These effects appear to result from suppression of ACh release from the myenteric motor neurons and are mediated by the D2 subtype of dopamine receptors. Itopride, by virtue of its dopamine D2 receptor antagonism, removes the inhibitory effects on Ach release. It also inhibits the enzyme AchE which prevents the degradation of ACh. The net effect is an increase in ACh concentration, which in turn, promotes gastric motility, increases the lower esophageal sphincter pressure, accelerates gastric emptying and improves gastro-duodenal coordination. This dual mode of action of Itopride is unique and different from the actions of other prokinetic agents available in the market.;
PRICE
29
DESCRIPTION
Itopride (HSR803) hydrochloride is a potent dopamine-2 antagonist and an acetylcholine esterase (AChE) inhibitor. Itopride hydrochloride enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, can be used as a gastrointestinal prokinetic agent. Itopride can be used for researching gastro-esophageal reflux disease (GERD)[1][2].
DESCRIPTION
Itopride is a dopamine D2 antagonist with acetylcholinesterase inhibitory actions. It is used for the treatment in gastrointestinal diseases and disorders (miscellaneous).
(Enamine Bioactive Compounds)
DESCRIPTION
Itopride hydrochloride (Ganaton) is an AChE and D2DR inhibitor.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
17
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
44
Molecular Weight
358.19
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
9
Ring Count
2
Aromatic Ring Count
2
cLogP
2.57
TPSA
60.03
Fraction CSP3
0.35
Chiral centers
0.0
Largest ring
6.0
QED
0.75
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
AChE
dopamine
CHRM3, DRD2
Bacterial
Cholinesterase (ChE)
Dopamine Receptor
AChR
Indication
dyspepsia, gastroparesis, heartburn, nausea, vomiting, anorexia
Disease Area
gastroenterology, neurology/psychiatry
MOA
Dopamine Receptor antagonist
Pathway
GPCR/G protein
Neuroscience
Anti-infection
Neuronal Signaling
Source data
