General
Preferred name
LETROZOLE
Synonyms
CGS 20267 ()
Femara ()
LT2 ()
4,4'-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile ()
LETROZOLE112809-51-5 ()
Letrozole (CGS 20267) ()
CGS 20267,Femara, Piroxicam ()
NSC-759652 ()
CGS-20267 ()
Letrozole-d4 ()
P&D ID
PD001661
CAS
112809-51-5
1133712-96-5
Tags
probe
natural product
drug
available
Approved by
PMDA
FDA
First approval
1997
Drug Status
investigational
approved
Drug indication
Hormonally-responsive breast cancer
Antineoplastic
Max Phase
Phase 4
Probe info
Probe selectivity
protein-selective
Probe type
P&D approved
calculated probe
Probe sources
High-quality chemical probes
Probe Miner (suitable probes)
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Letrozole is an oral non-steroidal aromatase (CYP19A1) inhibitor, with anti-estrogen action. (GtoPdb)
DESCRIPTION Potent AChE inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION Potent, reversible non-steroidal aromatase inhibitor (Tocriscreen Plus)
Cell lines
13
Organisms
0
Compound Sets
37
AdooQ Bioactive Compound Library
A10523
Axon Medchem Screening Library
3257
Cayman Chemical Bioactives
11568
26517
ChEMBL Approved Drugs
CHEMBL1444
ChEMBL Drugs
CHEMBL1444
Concise Guide to Pharmacology 2017/18
5209
Concise Guide to Pharmacology 2019/20
5209
Concise Guide to Pharmacology 2021/22
5209
Concise Guide to Pharmacology 2023/24
5209
Drug Repurposing Hub
DrugBank
DB01006
DrugBank Approved Drugs
DB01006
DrugCentral
1556
DrugCentral Approved Drugs
1556
DrugMAP
DMH07Y3
DrugMAP Approved Drugs
DMH07Y3
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
5209
High-quality chemical probes
PD001661
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1444
Mcule NIBR MoA Box Subset
MCULE-7693176754
MedChem Express Bioactive Compound Library
HY-14248
NCATS Inxight Approved Drugs
7LKK855W8I
NIH Approved Oncology Drugs
535027
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
Probe Miner (suitable probes)
P11511/1321721
ReFrame library
Selleckchem Bioactive Compound Library
Letrozole
TargetMol Bioactive Compound Library
T1590
The Spectrum Collection
Tocris Bioactive Compound Library
4382
Tocriscreen Plus
4382
ZINC Tool Compounds
ZINC000003778874
External IDs
40
Properties
(calculated by RDKit )
Molecular Weight
285.1
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
3
cLogP
2.66
TPSA
78.29
Fraction CSP3
0.06
Chiral centers
0.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Pathway
Endocrinology/Hormones
Autophagy
Metabolic Enzyme/Protease
Target
Aromatase
CYP19A1
Aromatase,Autophagy
Primary Target
Cytochrome P450
MOA
Inhibitor
Aromatase Inhibitors
Aromatase inhibitor
Member status
virtual
Indication
breast cancer
Therapeutic Class
Anticancer Agents
Source data