General
Preferred name
LEVOSIMENDAN
Synonyms
OR1259 ()
OR1855 ()
Simsndan ()
OR-1259 ()
OR1259,OR1855,Simsndan ()
Simendan, (r)- ()
(-)-OR-1259 ()
(r)-simendan ()
Simdax ()
NSC-759644 ()
P&D ID
PD001659
CAS
141505-33-1
131741-08-7
Tags
available
drug
Drug indication
Cardiac output syndrome
Pulmonary hypertension
Congestive heart failure
Heart failure
Drug Status
approved
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Levosimendan (Simsndan; OR-1259) is a calcium sensitiser used in the management of acutely decompensated congestive heart failure.
PRICE 29
DESCRIPTION Levosimendan (OR1259) is a calcium sensitizer used in the management of acutely decompensated congestive heart failure. It increases the sensitivity of the heart to calcium, thus increasing cardiac contractility without a rise in intracellular calcium. Levosimendan exerts its effect by increasing calcium sensitivity of myocytes by binding to cardiac troponin C in a calcium-dependent manner. (TargetMol Bioactive Compound Library)
Compound Sets
18
AdooQ Bioactive Compound Library
A11874
Cayman Chemical Bioactives
16128
ChEMBL Drugs
CHEMBL2051955
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00922
DrugBank Approved Drugs
DB00922
DrugCentral
1576
DrugCentral Approved Drugs
1576
DrugMAP
DMKBOS2
DrugMAP Approved Drugs
DMKBOS2
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL2051955
MedChem Express Bioactive Compound Library
HY-14286
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
levosimendan
TargetMol Bioactive Compound Library
T2530
The Spectrum Collection
External IDs
34
Properties
(calculated by RDKit )
Molecular Weight
280.11
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
1
cLogP
1.36
TPSA
113.43
Fraction CSP3
0.21
Chiral centers
1.0
Largest ring
6.0
QED
0.64
QED
0.64
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Autophagy
Membrane Transporter/Ion Channel
Metabolism
Metabolic Enzyme/Protease
Member status
member
MOA
Troponin C slow skeletal muscle stabilizer
Calcium sensitizer
K(ATP) Channel Activators
Nitric Oxide (NO) Production Inhibitors
Indication
congestive heart failure
Target
KCNJ11, KCNJ8, PDE3A, TNNC1
Phosphodiesterase (PDE)
Potassium Channel
Calcium Channel
Cardiac troponin C
phosphodiesterase
Therapeutic Class
Cardiotonic Agents
Source data