General
Preferred name
SULFANILAMIDE
Synonyms
Sulphanilamide ()
UK-124 ()
Sulfonamide ()
Sulphanilamidum ()
Prontosil i ()
Streptocid ()
Sulfamine ()
Aniline-p-sulfonic amide ()
P-aminobenzenesulfamide ()
P-aminobenzenesulfonamide ()
NSC-7618 ()
Prontylin ()
P&D ID
PD001658
CAS
63-74-1
102489-34-9
10103-15-8
Tags
natural product
drug
available
Approved by
FDA
First approval
1965
1985
Drug Status
approved
Drug indication
Bacterial infection
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Sulfanilamide is sulfonamide antimicrobial compound. It was first synthesized in 1908, but it was not until the 1930s that its antibacterial activity was discovered .
(GtoPdb)
DESCRIPTION
Sulfanilamide is a competitive inhibitor for bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
3
Organisms
2
Compound Sets
25
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
46
Molecular Weight
172.03
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
1
cLogP
-0.08
TPSA
86.18
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.58
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Autophagy
Anti-infection
Target
DHPS
CYP2C19, CYP2C9, CYP2D6, CYP2E1, CYP3A4
antibiotic
Bacterial
Member status
virtual
MOA
MEK1 Inhibitors
Carbonic anhydrase inhibitor
Indication
vulvovaginal candidiasis
Therapeutic Class
Antibiotics
Source data
