General
Preferred name
AZELAIC ACID
Synonyms
Nonanedioic acid ()
Finacea ()
Azelex ()
Anchoic acid ()
DISODIUM AZELATE ()
Skinoren ()
Nonanedioic acid, Finacea, Azelex, Anchoic acid ()
Azelate ()
ZK-62498 ()
ZK 62498 ()
Acido azelaico ()
NSC-19493 ()
Lepargylic acid ()
Acide azelaique ()
P&D ID
PD001656
CAS
123-99-9
17265-13-3
26776-28-3
Tags
available
drug
Approved by
FDA
First approval
1995
Drug indication
Rosacea
Acne vulgaris
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Azelaic acid is a saturated dicarboxylic acid, used clinically for its antibacterial and anti-inflammatory actions, as well as for its ability to inhibit keratin and melanin production.
(GtoPdb)
DESCRIPTION
Azelaic acid is a nine-carbon dicarboxylic acid. Azelaic acid has antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermidis through inhibition of microbial cellular prorein synthesis. Azelaic acid has hypopigmentation action resulting from its ability to scavenge free radicals[1][2].
PRICE
29
DESCRIPTION
Azelaic acid, produced by ozone cracking of unsaturated fatty acid, could be commonly used in grease, cosmetics and pharmaceuticals.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Antiproliferative on melonama cells; inhibits mitochondrial oxidoreductases of the respiratory chain and inhibits DNA synthesis
(LOPAC library)
DESCRIPTION
Azelaic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and barley. It is used for the topical treatment of mild-to-moderate inflammatory acne vulgaris. It is thought that azelaic acid manifests its antibacterial effects by inhibiting the synthesis of cellular protein in anaerobic and aerobic bacteria.
(Enamine Bioactive Compounds)
DESCRIPTION
Azelaic acid (Anchoic acid) is a component of hair and skin conditioners and is produced by the ozonolysis of oleic acid. Azelaic acid has bacteriostatic activity against Propionibacterium acnes and Staphylococcus epidermidis by inhibiting protoprotein synthesis in microbial cells. Azelaic acid also has the ability to inhibit pigmentation due to its free radical scavenging action.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
27
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LOPAC library
MedChem Express Bioactive Compound Library
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
59
Molecular Weight
188.1
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
0
Aromatic Ring Count
0
cLogP
1.89
TPSA
74.6
Fraction CSP3
0.78
Chiral centers
0.0
Largest ring
0.0
QED
0.57
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
DNA polymerase I
Endogenous Metabolite
ThxR
AKR1D1, SRD5A2, TYR
antibiotic
Bacterial
Indication
rosacea
MOA
tyrosinase inhibitor
Biosynthetic Origin
Fatty Acid
Therapeutic Indication
Antiacne
Therapeutic Class
Dermatologic Agents
Pathway
Cell Cycle/Checkpoint
DNA Damage/DNA Repair
Metabolism
Anti-infection
Metabolic Enzyme/Protease
Solubility
10 mM in DMSO
Source data
