General
Preferred name
AZELAIC ACID
Synonyms
Nonanedioic acid ()
Finacea ()
Azelex ()
Anchoic acid ()
DISODIUM AZELATE ()
Skinoren ()
Nonanedioic acid, Finacea, Azelex, Anchoic acid ()
ZK-62498 ()
Lepargylic acid ()
ZK 62498 ()
NSC-19493 ()
Azelate ()
P&D ID
PD001656
CAS
123-99-9
17265-13-3
26776-28-3
Tags
natural product
drug
available
Approved by
FDA
First approval
1995
Drug Status
approved
Drug indication
Anti-Acne
Acne vulgaris
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Azelaic acid is a saturated dicarboxylic acid, used clinically for its antibacterial and anti-inflammatory actions, as well as for its ability to inhibit keratin and melanin production.
(GtoPdb)
DESCRIPTION
Antiproliferative on melonama cells; inhibits mitochondrial oxidoreductases of the respiratory chain and inhibits DNA synthesis
(LOPAC library)
DESCRIPTION
Azelaic acid, produced by ozone cracking of unsaturated fatty acid, could be commonly used in grease, cosmetics and pharmaceuticals.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
25
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LOPAC library
MedChem Express Bioactive Compound Library
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
57
Molecular Weight
188.1
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
0
Aromatic Ring Count
0
cLogP
1.89
TPSA
74.6
Fraction CSP3
0.78
Chiral centers
0.0
Largest ring
0.0
QED
0.57
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
DNA Damage/DNA Repair
Anti-infection
Metabolic Enzyme/Protease
Target
DNA polymerase I
ThxR
AKR1D1, SRD5A2, TYR
antibiotic
Endogenous Metabolite
Bacterial
Indication
rosacea
MOA
tyrosinase inhibitor
Biosynthetic Origin
Fatty Acid
Therapeutic Indication
Antiacne
Therapeutic Class
Dermatologic Agents
Solubility
10 mM in DMSO
Source data
