General
Preferred name
ACEMETACIN
Synonyms
K-708 ()
TVX 1322 ()
Acemetacin (Emflex) ()
K-708,TVX 1322 ()
Acemetacina ()
Rantudil ()
Acemetacine ()
NSC-757413 ()
Emflex ()
P&D ID
PD001649
CAS
53164-05-9
Tags
available
drug
Drug Status
approved
investigational
Max Phase
2.0
Drug indication
rheumatic disease
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Acemetacin (TVX 1322) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.
DESCRIPTION Acemetacin (TVX 1322) is a carboxymethyl ester of indometacin and a potent non-steroidal anti-inflammatory drug derived from indol-3-acetic acid, with its activity primarily attributed to its active metabolite, indomethacin. In clinical trials, acemetacin shows better gastric tolerability compared to indomethacin. (TargetMol Bioactive Compound Library)
Compound Sets
16
AdooQ Bioactive Compound Library
A11692
Cayman Chemical Bioactives
29615
ChEMBL Drugs
CHEMBL189171
Drug Repurposing Hub
DrugBank
DB13783
DrugBank Approved Drugs
DB13783
DrugCentral
47
DrugCentral Approved Drugs
47
DrugMatrix
MedChem Express Bioactive Compound Library
HY-B0482
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
acemetacin-emflex
TargetMol Bioactive Compound Library
T1467
The Spectrum Collection
External IDs
33
Properties
(calculated by RDKit )
Molecular Weight
415.08
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
3
cLogP
3.47
TPSA
94.83
Fraction CSP3
0.19
Chiral centers
0.0
Largest ring
6.0
QED
0.62
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
COX
PTGS1, PTGS2
Indication
osteoarthritis
MOA
cyclooxygenase inhibitor
Pathway
Immunology/Inflammation
Neuroscience
Source data