General
Preferred name
QUERCETIN
Synonyms
ML061 Analog ()
2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4h-chromen-4-one ()
QUERCETIN DIHYDRATE ()
Sophoretin ()
Quercetine dihydrate ()
Quercetin (Sophoretin) ()
Flavonoid derivative 4 ()
Quercetin (dihydrate) ()
Sophoretin, C.I. 75720 ()
Quercetin (NSC 9221) ()
Quercetin (hydrate) ()
3'-hydroxykaempferol ()
C.I. Natural Red 1 ()
Lipoflavon ()
Quercetol ()
NSC-9219 ()
Corvitin ()
LDN-0052529 ()
Quertine ()
C.i. 75670 ()
Cyanidenolon 1522 ()
Ci-75670 ()
Quercetine ()
Quertin ()
NSC 9219 ()
Quercetin (constituent of ginkgo) ()
Xanthaurine ()
NSC 57655 ()
Meletin ()
NSC-57655 ()
Korvitin ()
LDN 0052529 ()
Quercetin-d3 (hydrate) ()
P&D ID
PD001643
CAS
117-39-5
6151-25-3
849061-97-8
Tags
available
drug
natural product
nuisance
obsolete probe
Drug indication
Chronic obstructive pulmonary disease
Obesity
Drug Status
approved
experimental
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Quercetin is a plant flavonoid. It is used as an ingredient in dietary supplements, beverages, and foods, and has been investigated for potential anti-inflammatory and senolytic-like actions. (GtoPdb)
DESCRIPTION Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 ¦ÌM, 3.0 ¦ÌM and 5.4 ¦ÌM for PI3K ¦Ã, PI3K ¦Ä and PI3K ¦Â, respectively[1].
PRICE 29
DESCRIPTION Quercetin, a flavonoid natural product, is a SIRT1 activator. It is also a PI3K inhibitor, inhibiting PI3K??, PI3K??, and PI3K?? with IC50 values of 2.4, 3.0, and 5.4 ??M, respectively. Recognized as a heat shock protein inhibitor, Quercetin can significantly reduce exosome release in TII models by downregulating Hsp70 or Hsp90.
DESCRIPTION Quercetin dihydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC50s of 2.4 ¦ÌM, 3.0 ¦ÌM and 5.4 ¦ÌM for PI3K ¦Ã, PI3K ¦Ä and PI3K ¦Â, respectively[1].
PRICE 29
DESCRIPTION Prototypical PI 3-kinase inhibitor; also inhibits other kinases (Tocris Bioactive Compound Library)
DESCRIPTION Mitochondrial ATPase and phosphodiesterase (PDE) inhibitor; inhibits PI3-K activity (LOPAC library)
DESCRIPTION Non-selective PI 3-kinase inhibitor (Tocriscreen Total)
DESCRIPTION Quercetin is a natural flavonoid found in foods and natural supplement products. It is the most prominent dietary antioxidant. Quercetin inhibits sulfotransferase, IC50=12 pM. (Enamine Bioactive Compounds)
DESCRIPTION Quercetin, a flavonoid natural product, is a SIRT1 activator. It is also a PI3K inhibitor, inhibiting PI3Kγ, PI3Kδ, and PI3Kβ with IC50 values of 2.4, 3.0, and 5.4 μM, respectively. Recognized as a heat shock protein inhibitor, Quercetin can significantly reduce exosome release in TII models by downregulating Hsp70 or Hsp90. (TargetMol Bioactive Compound Library)
DESCRIPTION Quercetin Dihydrate (Sophoretin) is a polyphenolic flavonoid that was found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine. It is used for their nervous system and anticancer effects. (TargetMol Bioactive Compound Library)
Cell lines
62
Organisms
13
Compound Sets
32
A Collection of Useful Nuisance Compounds (CONS) for Interrogation of Bioassay Integrity
AdooQ Bioactive Compound Library
A10766
A10765
Cayman Chemical Bioactives
10005169
26418
ChEMBL Drugs
CHEMBL50
Drug Repurposing Hub
DrugBank
DB04216
DrugCentral
3514
DrugCentral Approved Drugs
3514
DrugMAP
DM3NC4M
DMMOSVD
DrugMAP Approved Drugs
DM3NC4M
Enamine Bioactive Compounds
EBC-11067
Enamine BioReference Compounds
Guide to Pharmacology
5346
IPPI - DB
1720
Ki Database
Quercetin
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL50
Mcule NIBR MoA Box Subset
MCULE-2433372790
MedChem Express Bioactive Compound Library
HY-18085
HY-N0146
MLSMR Probes +
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Nuisance compounds in cellular assays
Obsolete Compounds
quercetin
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
Quercetin(Sophoretin)
Quercetin-dihydrate(Sophoretin)
TargetMol Bioactive Compound Library
T2174
T6630
The Spectrum Collection
Tocris Bioactive Compound Library
1125
Tocriscreen Total
ZINC Tool Compounds
ZINC000003869685
External IDs
84
Properties
(calculated by RDKit )
Molecular Weight
302.04
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
5
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
3
cLogP
1.99
TPSA
131.36
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.43
Structural alerts
5
aggregator (Aggregator Advisor)
Aggregators
historic compounds (Chemical Probes.org)
Obsolete
aggregator (ZINC)
Aggregators
Aggregation
Nuisance compounds
Nonspecific/NOS
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Classification
probe analog
Selectivity
PDE
Target
Apoptosis
PI3K
ATP5A1, ATP5B, ATP5C1, HCK, HIBCH, PIK3CG, PIM1, STK17B, UGT3A1
Mitophagy
Reactive Oxygen Species (ROS)
Apoptosis related,Autophagy,Mitophagy,PI3K,PKC,Sirtuin,Src
PI3K,Sirtuin
PI3Kγ
PI3Kδ
Reactive Oxygen Species
Primary Target
PI 3-kinase
MOA
Inhibitor
polar auxin transport inhibitor
Member status
virtual
Indication
fatigue, allergic rhinitis, drowsiness
Disease Area
neurology/psychiatry, allergy
Pathway
Autophagy
Immunology/Inflammation
Metabolism
NF-κB
PI3K/Akt/mTOR signaling
Metabolic Enzyme/Protease
PI3K/Akt/mTOR
NF-¦ÊB
Therapeutic Class
Hypoglycemic Agents
Nuisance MOA
Colloidal aggregates
Targets
Monoamine oxidase A Cytochrome P450 19A1 Aldose reductase
Source data