General
Preferred name
MYCOPHENOLIC ACID
Synonyms
Mycophenolic acid D3 ()
Mycophenolate D3 ()
Mycophenolate ()
RS-61443 ()
RS-61443 D3 ()
Mycophenolic acid (sodium) ()
Mycophenolate (sodium) ()
Mycophenolate, RS-61443 ()
MYCOPHENOLATE SODIUM ()
4-Methylumbelliferyl-?-L-Iduronide 2-sulfate (sodium salt) ()
Mycophenolic Acid ()
Mycophenolate mofetil impurity, mycophenolic acid- ()
Acide mycophenolique ()
RS-61443 [as mofetil] ()
Acido micofenolico ()
68618 ()
NSC-129185 ()
Sodium mycophenolate ()
ERL-080 ()
NSC-116072 ()
Myfortic ()
Mycophenolic sodium ()
Sodium mycophenalate ()
ERL 080 ()
Ceptava ()
Mycophenolic acid sodium salt ()
Mycophenolic sod ()
P&D ID
PD001641
CAS
24280-93-1
483-60-3
1162256-90-7
37415-62-6
2181774-46-7
Tags
available
drug
natural product
Approved by
FDA
First approval
2004
Drug indication
Autoimmune disease
acute graft vs. host disease
Middle East Respiratory Syndrome (MERS)
Organ transplant rejection
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION An antibacterial substance derived from Penicillium stoloniferum, and related species. Inhibits inosine-5'-monophosphate dehydrogenase (IMPDH). (GtoPdb)
DESCRIPTION Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 ¦ÌM.?Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects[1][2].
PRICE 29
DESCRIPTION Mycophenolic acid sodium is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 ¦ÌM. Mycophenolic acid sodium demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid sodium is an immunosuppressive agent. Antiangiogenic and antitumor effects[1][2].
DESCRIPTION Cyclooxygenase (COX-1) inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION Inosine monophosphatase dehydrogenase inhibitor (Tocriscreen Plus)
DESCRIPTION Inosine monophosphatase dehydrogenase inhibitor (Tocriscreen Total)
DESCRIPTION Mycophenolic acid is an an immunosuppresant drug and potent anti-proliferative, and can be used in place of the older anti-proliferative azathioprine. It is usually used as part of triple therapy including a calcineurin inhibitor and prednisolone. (Enamine Bioactive Compounds)
DESCRIPTION Mycophenolic acid (Mycophenolate) is an inosine monophosphate dehydrogenase(IMPDH) inhibitor with anti-proliferative activity. (TargetMol Bioactive Compound Library)
Cell lines
22
Organisms
24
Compound Sets
35
AdooQ Bioactive Compound Library
A10614
Cayman Chemical Bioactives
21716
9001600
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL866
CHEMBL2106643
ChEMBL Drugs
CHEMBL866
CHEMBL2106643
Concise Guide to Pharmacology 2017/18
6832
Concise Guide to Pharmacology 2019/20
6832
Concise Guide to Pharmacology 2021/22
6832
Concise Guide to Pharmacology 2023/24
6832
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB01024
DrugBank Approved Drugs
DB01024
DrugCentral
1860
DrugCentral Approved Drugs
1860
DrugMAP
DMU65NK
DMYTN18
DrugMAP Approved Drugs
DMYTN18
Enamine Bioactive Compounds
EBC-11149
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100675
Guide to Pharmacology
6832
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL866
MedChem Express Bioactive Compound Library
HY-B0421
HY-B0421A
NCATS Inxight Approved Drugs
HU9DX48N0T
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
Mycophenolic-acid(Mycophenolate)
TargetMol Bioactive Compound Library
T1335
The Spectrum Collection
Tocris Bioactive Compound Library
1505
Tocriscreen Plus
1505
Tocriscreen Total
ZINC Tool Compounds
ZINC000000001758
External IDs
70
Properties
(calculated by RDKit )
Molecular Weight
320.13
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
1
cLogP
2.73
TPSA
93.06
Fraction CSP3
0.41
Chiral centers
0.0
Largest ring
6.0
QED
0.62
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
MOA
bacterial inosine-5-monophosphate dehydrogenase inhibitor
Inhibitor
Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitors
Immunosuppressant
IMPDH inhibitor
Antiviral
dehydrogenase inhibitor, inositol monophosphatase inhibitor
Target
Inosine-5'-monophosphate dehydrogenase (IMPDH)
IMPDH1, IMPDH2
antibiotic
Bacterial
Dengue virus
Endogenous Metabolite
Flavivirus
Fungal
Antineoplastic and Immunosuppressive Antibiotics,Dehydrogenase,Selection Antibiotics for Transfected Cell
DH
UGT
Pathway
Apoptosis
Metabolism
Microbiology/virology
Anti-infection
Metabolic Enzyme/Protease
Primary Target
Other Dehydrogenases
Member status
virtual
Indication
organ rejection
Therapeutic Class
Antiviral Agents
Source data