General
Preferred name
CAPTOPRIL
Synonyms
SA333 ()
SQ-14534 ()
SQ 14225 ()
SQ 14225,Capoten ()
Garranil ()
Captoprilum ()
Hyteneze 50 ()
Apopril ()
Tensiomin ()
Kaplon ()
C09AA01 ()
Hyteneze 25 ()
Captomax ()
Mepha ()
Captomex ()
Acepril ()
Lopril ()
SQ -14225 ()
Zapto ()
NSC-757419 ()
Tensobon ()
SQ-14225 ()
Capoten ()
SQ 14,225 ()
Noyada ()
SA-333 ()
Ecopace ()
Farcopril ()
Hyteneze 12.5 ()
Hypopress ()
Captopril-d3 ()
P&D ID
PD001635
CAS
62571-86-2
1356383-38-4
Tags
natural product
drug
available
Approved by
FDA
First approval
1981
Drug Status
approved
Drug indication
Coronavirus Disease 2019 (COVID-19)
Hypertension
Enzyme Inhibitor (angiotensin-converting)
Antihypertensive
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Captopril is a potent, competitive angiotensin-converting enzyme (ACE) inhibitor, and is one of the few that is not a prodrug. (GtoPdb)
DESCRIPTION Angiotensin-converting enzyme (ACE) inhibitor; antihypertensive (LOPAC library)
Compound Sets
30
AdooQ Bioactive Compound Library
A11738
Cayman Chemical Bioactives
15313
25235
ChEMBL Approved Drugs
CHEMBL1560
ChEMBL Drugs
CHEMBL1560
Concise Guide to Pharmacology 2017/18
5158
Concise Guide to Pharmacology 2019/20
5158
Concise Guide to Pharmacology 2021/22
5158
Concise Guide to Pharmacology 2023/24
5158
Drug Repurposing Hub
DrugBank
DB01197
DrugBank Approved Drugs
DB01197
DrugCentral
484
DrugCentral Approved Drugs
484
DrugMAP
DM458UM
DMMZDJ6
DrugMAP Approved Drugs
DM458UM
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101434
Guide to Pharmacology
5158
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1560
MedChem Express Bioactive Compound Library
HY-B0368
NCATS Inxight Approved Drugs
9G64RSX1XD
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
captopril-capoten
TargetMol Bioactive Compound Library
T1462
The Spectrum Collection
ZINC Tool Compounds
ZINC000000057001
External IDs
41
Properties
(calculated by RDKit )
Molecular Weight
217.08
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
1
Aromatic Ring Count
0
cLogP
0.63
TPSA
57.61
Fraction CSP3
0.78
Chiral centers
2.0
Largest ring
5.0
QED
0.68
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
ACE
Pathway
Endocrinology/Hormones
Metabolic Enzyme/Protease
Indication
hypertension, congestive heart failure, myocardial infarction, diabetes mellitus, diabetic nephropathy
Disease Area
cardiology, endocrinology, nephrology
Target
ACE, LTA4H, MMP2, MMP9
Angiotensin-converting Enzyme (ACE)
ACE,RAAS
MOA
angiotensin converting enzyme inhibitor
Therapeutic Class
Antihypertensive Agents
Antiviral Agents
Source data