General
Preferred name
kynurenic acid
Synonyms
Kynurenic acid (sodium) ()
Kynurenate ()
Quinurenic acid|Kynurenate ()
Kynurenic acid sodium salt ()
NSC 58973 ()
Transtorine (Kynurenic acid) ()
TRANSTORINE ()
Quinurenic acid ()
Quinurenic acid, Kynurenate ()
Kynurenic Acid ()
Kynurenic Acid (hydrate) ()
Kynurenic Acid-d5 ()
P&D ID
PD001631
CAS
492-27-3
2439-02-3
13593-94-7
345909-35-5
350820-13-2
Tags
drug candidate
natural product
available
Drug indication
Discovery agent
Drug Status
investigational
Max Phase
Phase 1
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Kynurenic acid is a by-product of the kynurenine pathway, the main route for the non-protein metabolism (catabolism) of tryptophan . (GtoPdb)
DESCRIPTION Endogenous NMDA agonist and transmitter candidate (Tocris Bioactive Compound Library)
DESCRIPTION Potent NMDA antagonist, acts at glycine site; sodium salt of 5,7-Dichlorokynurenic acid (Tocris Bioactive Compound Library)
DESCRIPTION Broad spectrum EAA antagonist (Tocriscreen Plus)
DESCRIPTION Excitatory amino acid receptor antagonist; blocks kainic acid-induced neurotoxicity; metabolite of tryptophan (LOPAC library)
DESCRIPTION Broad spectrum EAA antagonist (Tocriscreen Total)
DESCRIPTION Kynurenic acid sodium salt is the sodium form of kynurenic acid, which is a broad spectrum EAA antagonist. (BOC Sciences Bioactive Compounds)
DESCRIPTION Kynurenic acid is a product of L-Tryptophan metabolism. It is a non-selective antagonist at NMDA and AMPA/kainate receptors. It could block kainic acid neurotoxicity. It has neruoactive activity having anticonvulsant and antiexcitotoxic properties. (BOC Sciences Bioactive Compounds)
Compound Sets
25
BOC Sciences Bioactive Compounds
kynurenic-acid-cas-492-27-3-item-93040
kynurenic-acid-sodium-salt-cas-2439-02-3-item-169585
Cayman Chemical Bioactives
16792
36306
ChEMBL Drugs
CHEMBL299155
Concise Guide to Pharmacology 2017/18
2918
Concise Guide to Pharmacology 2019/20
2918
Concise Guide to Pharmacology 2021/22
2918
Concise Guide to Pharmacology 2023/24
2918
Drug Repurposing Hub
DrugBank
DB11937
DrugMAP
DMP4T87
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101762
Guide to Pharmacology
2918
Ki Database
Kynurenate
LOPAC library
MedChem Express Bioactive Compound Library
HY-100806
HY-W110662
HY-107512
Novartis Chemogenetic Library (NIBR MoA Box)
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
kynurenic-acid
The Spectrum Collection
Tocris Bioactive Compound Library
0223
3694
Tocriscreen Plus
0223
Tocriscreen Total
External IDs
57
Properties
(calculated by RDKit )
Molecular Weight
189.04
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
2
cLogP
1.64
TPSA
70.42
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.71
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
Selectivity
NMDA-Glycine
Pathway
Neuronal Signaling
GPCR/G protein
Immunology/Inflammation
Membrane Transporter/Ion Channel
Apoptosis
Metabolic Enzyme/Protease
Anti-infection
Target
CXCR
iGluR
¦Á7 nicotinic acetylcholine receptor
glutamate receptors
GPR35, GRIN1, GRIN2A, GRIN2B
Endogenous Metabolite
GPR35
Bacterial
NMDAR
Primary Target
Non-selective Ionotropic Glutamate
MOA
AChR antagonist
GluR antagonist
Antagonist
NMDA Antagonists
AMPA Receptor Modulators
a7 nicotinic acetylcholine receptor Inhibitor
glutamate receptor antagonist
Member status
member
Source data