General
Preferred name
N-acetylserotonin
Synonyms
ACETYLSEROTONIN ()
N-Acetyl-5-hydroxytryptamine ()
Serotonin,N-acetyl ()
Normelatonin ()
O-Demethylmelatonin ()
NAS, N-Acetylserotonin, Normelatonin, O-Demethylmelatonin ()
N-Acetylserotonin ()
P&D ID
PD001627
CAS
1210-83-9
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION N-Acetyl-5-hydroxytryptamine is a Melatonin precursor, and that it can potently activate TrkB receptor.
PRICE 29
DESCRIPTION N-Acetylserotonin is the immediate precursor of melatonin. It is a neurotransmitter and acts as an agonist at the melatonin receptors (Ki=7.7 nM). It also inhibits 5-Hydroxytryptamine 1A receptor with Ki=1.5 nM. (Enamine Bioactive Compounds)
DESCRIPTION Immediate precursor of melatonin (LOPAC library)
DESCRIPTION N-Acetyl-5-hydroxytryptamine (O-Demethylmelatonin) , also known as Normelatonin, is the immediate precursor of melatonin. It is produced from serotonin by the enzyme aralkylamine N-acetyltransferase and is converted to melatonin by acetylserotonin O-methyltransferase. It can potently activate TrkB receptor. (TargetMol Bioactive Compound Library)
Compound Sets
11
Cayman Chemical Bioactives
33681
14535
DrugBank
DB04275
DrugMAP
DMJ4SBM
Enamine Bioactive Compounds
EBC-47422
Guide to Pharmacology
5451
Ki Database
Serotonin,N-acetyl
LOPAC library
MedChem Express Bioactive Compound Library
HY-107854
Selleckchem Bioactive Compound Library
n-acetyl-5-hydroxytryptamine
TargetMol Bioactive Compound Library
T1354
The Spectrum Collection
External IDs
37
Properties
(calculated by RDKit )
Molecular Weight
218.11
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
1.55
TPSA
65.12
Fraction CSP3
0.25
Chiral centers
0.0
Largest ring
6.0
QED
0.73
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Endogenous Metabolite
Trk Receptor
TrkB
MOA
Trk receptor
Pathway
Metabolic Enzyme/Protease
Neuronal Signaling
Protein Tyrosine Kinase/RTK
Metabolism
Tyrosine Kinase/Adaptors
Source data