General
Preferred name
physostigmine
Synonyms
PHYSOSTIGMINE SULFATE ()
PHYSOSTIGMINE SALICYLATE ()
(-)-Physostigmine ()
Eserine sulfate, physostigmine sulfate ()
Eserine hemisulfate salt ()
Physostigmine (salicylate) ()
Eserine (salicylate) ()
Eserine ()
Physostigmine hemisulfate ()
Salicylic acid compd. with physostigmine (1:1) ()
Eserinum ()
NSC-30782 ()
MCV-4484 ()
Eserin ()
Cogmine ()
NSC-757275 ()
Antilirium ()
Physostigmine monosalicylate ()
Physostigmini salicylas ()
Physostigmine sulfate (2:1) ()
Physostigmine sulphate (2:1) ()
Physostigmine sulphate ()
(-)-Physostigmine (salicylate) ()
P&D ID
PD001599
CAS
57-47-6
57-64-7
11033-04-8
11036-67-2
50975-37-6
64-47-1
Tags
available
covalent binder
natural product
drug
drug candidate
First approval
1875
Drug indication
Pain
Xerostomia
Drug Status
approved
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Physostigmine, originally isolated from the Calabar bean, is a parasympathomimetic alkaloid, acting as a reversible cholinesterase inhibitor (the enzyme responsible for the breakdown of acetylcholine in the synaptic cleft of the neuromuscular junction). (GtoPdb)
DESCRIPTION Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning[1][2][3][4].
DESCRIPTION Physostigmine salicylate (Eserine salicylate) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine salicylate crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine salicylate can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine salicylate is also an antidote for anticholinergic poisoning[1][2][3][4].
PRICE 162
DESCRIPTION Cholinesterase inhibitor (LOPAC library)
DESCRIPTION Physostigmine, a parasympathomimetic alkaloid, is a reversible cholinesterase inhibitor. It extracts from the Calabar bean. (TargetMol Bioactive Compound Library)
DESCRIPTION Physostigmine hemisulfate, a derivative of Physostigmine, is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
26
BOC Sciences Bioactive Compounds
physostigmine-hemisulfate-cas-64-47-1-item-31008
Cayman Chemical Bioactives
33106
ChEMBL Drugs
CHEMBL94
CHEMBL338975
CHEMBL2105891
Concise Guide to Pharmacology 2017/18
6598
Concise Guide to Pharmacology 2019/20
6598
Concise Guide to Pharmacology 2021/22
6598
Concise Guide to Pharmacology 2023/24
6598
CovalentInDB
CI002082
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00981
DrugBank Approved Drugs
DB00981
DrugCentral
2159
DrugCentral Approved Drugs
2159
DrugMAP
DM2N0TO
Guide to Pharmacology
6598
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL94
MedChem Express Bioactive Compound Library
HY-N6608
HY-B1266
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
TargetMol Bioactive Compound Library
T0130
The Spectrum Collection
ZINC Tool Compounds
ZINC000091689892
External IDs
92
Properties
(calculated by RDKit )
Molecular Weight
275.16
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
1
cLogP
1.77
TPSA
44.81
Fraction CSP3
0.53
Chiral centers
2.0
Largest ring
6.0
QED
0.85
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Cholinesterase
Target
AChE
AChR
ACHE, BCHE
Cholinesterase (ChE)
Indication
hypotension, Alzheimer's disease, glaucoma, gastroparesis
Disease Area
cardiology, neurology/psychiatry, ophthalmology, gastroenterology
MOA
acetylcholinesterase inhibitor, cholinesterase inhibitor
Pathway
Neuroscience
Neuronal Signaling
Solubility
DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
Source data