General
Preferred name
NALIDIXIC ACID
Synonyms
Nalidixic acid sodium ()
NSC-82174 ()
Baktogram ()
Nalidixic acid sodium salt hydrate ()
Nalidixic acid sodium salt ()
Nalidixic acid ()
Nalidixic acid (sodium salt) ()
NALIDIXATE SODIUM ()
WIN-18320 ()
Nalidixate ()
Nalidixane ()
Neg Gram ()
Wintomylon ()
Nalix ()
Uroneg ()
Negram ()
Neggram ()
Uriben ()
WIN 18,320 ()
Mictral ()
WIN 18,320-3 ()
Nalidixate sodium anhydrous ()
Nalidixate sodium monohydrate ()
Sodium nalidixate ()
WIN-18320-3 ()
P&D ID
PD001597
CAS
389-08-2
3374-05-8
15769-77-4
Tags
drug candidate
natural product
drug
available
Approved by
FDA
First approval
1964
Drug Status
investigational
approved
withdrawn
Drug indication
Antibacterial
Urinary tract infection
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
ROE Following oral administration, NegGram is rapidly absorbed from the gastrointestinal tract, partially metabolized in the liver, and rapidly excreted through the kidneys.; Approximately four percent of NegGram is excreted in the feces.
DESCRIPTION Nalidixic acid is a 1,8-naphthyridine derivative belonging to the quinolone class of antibacterial compounds, with activity against Gram-negative bacteria . (GtoPdb)
DESCRIPTION Inhibits bacterial DNA polymerase (DNA gyrase) (LOPAC library)
Cell lines
0
Organisms
1
Compound Sets
26
Cayman Chemical Bioactives
19807
ChEMBL Approved Drugs
CHEMBL5
ChEMBL Drugs
CHEMBL5
CHEMBL1255939
Drug Repurposing Hub
DrugBank
DB00779
DrugBank Approved Drugs
DB00779
DrugCentral
1875
DrugCentral Approved Drugs
1875
DrugMAP
DMRM0JV
DrugMAP Approved Drugs
DMRM0JV
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100389
Guide to Pharmacology
12773
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL5
MedChem Express Bioactive Compound Library
HY-B0398
HY-B0398A
NIH Clinical Collections (NCC)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Nalidixic-acid(NegGram)
TargetMol Bioactive Compound Library
T0909
The Spectrum Collection
Withdrawn 2.0
339
External IDs
64
Properties
(calculated by RDKit )
Molecular Weight
232.08
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
2
cLogP
1.42
TPSA
72.19
Fraction CSP3
0.25
Chiral centers
0.0
Largest ring
6.0
QED
0.85
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
DNA Gyrase
Pathway
DNA Damage/DNA Repair
Anti-infection
Cell Cycle/DNA Damage
Target
Topo II
antibiotic
Bacterial
Topoisomerase
Selection Antibiotics for Transfected Cell,Topoisomerase
Indication
urinary tract infections
MOA
bacterial DNA gyrase inhibitor
ATC
J01MB02
Therapeutic Class
Antibiotics
Source data