General
Preferred name
CEFACLOR
Synonyms
Cefachlor ()
Cefaclorum ()
Cefaclor monohydrate ()
Loracarbef ()
CEFACLOR HYDRATE ()
CEFACLOR ANHYDROUS ()
Cefachlor, Cefaclorum ()
Cefaclor hydrate ()
Raniclor ()
Ceclor ()
Compound 99638 ()
Cefaclor ()
Distaclor ()
Bacticlor MR ()
Ceclor Cd ()
Keftid ()
NSC-757422 ()
COMPOUND-99638 ()
J01DC04 ()
Distaclor MR ()
P&D ID
PD001586
CAS
70356-03-5
53994-73-3
121961-22-6
Tags
natural product
drug
available
Approved by
FDA
First approval
1979
Drug Status
approved
Drug indication
Bacterial infection
Antibacterial
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS
Cefaclor is a second generation cephalosporin antibiotic with a spectrum resembling first-generation cephalosporins. In vitro tests demonstrate that the bactericidal action of the cephalosporins results from inhibition of cell-wall synthesis. As indicated by _in vitro_ and _in vivo_ clinical studies, cefaclor was shown to be effective against most strains of Gram positive aerobes - Staphylococci (including coagulase-positive, coagulase-negative, and penicillinase-producing strains), Streptococcus pneumoniae, Streptococcus pyogenes (group A ß-hemolytic streptococci), as well as Gram-negative aerobes - Escherichia coli, Haemophilus influenzae (including ß-lactamase-producing ampicillin-resistant strains), Klebsiella sp, and Proteus mirabilis.
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
20
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
54
Molecular Weight
367.04
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
1
cLogP
0.62
TPSA
112.73
Fraction CSP3
0.27
Chiral centers
3.0
Largest ring
6.0
QED
0.67
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Microbiology&virology
Anti-infection
Target
PBPs
antibiotic
Bacterial
Penicillin-binding protein (PBP)
Disease Area
infectious disease, otolaryngology
Indication
pneumonia, skin infections, urinary tract infections, respiratory tract infections, tonsillitis, pharyngitis
MOA
bacterial cell wall synthesis inhibitor
Therapeutic Class
Antibiotics
Source data
