General
Preferred name
ADENINE
Synonyms
B 4, vitami ()
Adenine hydrochloride hydrate ()
6-Aminopurine hydrochloride hydrate ()
Vitamin B4 ()
6-Aminopurine ()
Adenine HCl ()
6-Aminopurine hydrochloride ()
Diadenine sulphate ()
Adenine sulfate ()
Adeninsulfat ()
Adenine (hydrochloride) ()
Adenine (hemisulfate) ()
Adenine monohydrochloride hemihydrate ()
6-Aminopurine (hydrochloride) ()
Vitamin B4 (hydrochloride) ()
6-Aminopurine (hemisulfate) ()
Vitamin B4 (hemisulfate) ()
Adenine hemisulfate ()
Adenine Hydrochloride Hemihydrate ()
Adenine hydrochloride ()
NSC-14666 ()
Adenine-15N5 (hydrochloride hydrate) ()
P&D ID
PD001577
CAS
73-24-5
2922-28-3
22051-90-7
6055-72-7
321-30-2
Tags
available
drug
Approved by
FDA
First approval
2021
Drug indication
Malnutrition
septic shock
Drug Status
approved
investigational
nutraceutical
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA
Adenine forms adenosine, a nucleoside, when attached to ribose, and deoxyadenosine when attached to deoxyribose, and it forms adenosine triphosphate (ATP), which drives many cellular metabolic processes by transferring chemical energy between reactions.
DESCRIPTION
Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. ;Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis[1][2][3].
PRICE
29
PRICE
25
DESCRIPTION
Adenine hydrochloride (6-Aminopurine hydrochloride), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine hydrochloride acts as a chemical component of DNA and RNA. Adenine hydrochloride also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis[1][2][3].
PRICE
29
DESCRIPTION
Adenine monohydrochloride hemihydrate is an endogenous metabolite.
PRICE
29
DESCRIPTION
Adenine monohydrochloride hemihydrate is a high affinity adenine receptor agonist (Ki = 18 nM at rat adenine receptor). It inhibits forskolin-stimulated cAMP formation in CHO cells transfected with the adenine receptor and also stimulates GTP??S binding (pEC50 values are 8.54 and 7.21 respectively).
DESCRIPTION
Adenine hemisulfate (6-Aminopurine hemisulfate), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine hemisulfate acts as a chemical component of DNA and RNA. Adenine hemisulfate also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis[1][2].
DESCRIPTION
Adenine is a purine base which forms a component of DNA among other functions and is present in many multivitamins. Adenine combines with the sugar ribose to form adenosine, which in turn can be bonded with from one to three phosphoric acid units, yielding AMP, ADP and ATP .
(Enamine Bioactive Compounds)
DESCRIPTION
Adenine (6-Aminopurine), a purine derivative, is a nucleobase essential in biochemistry, participating in cellular respiration through ATP, NAD, and FAD, and in protein synthesis as a component of DNA and RNA.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Adenine hemisulfate (Diadenine sulphate) is a sulfate salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Selective GAT-1 inhibitor; anticonvulsant
(Tocris Bioactive Compound Library)
DESCRIPTION
Adenine hydrochloride (6-Aminopurine hydrochloride) is a hydrochloride salt form of adenine which is a nucleobase with a variety of roles in biochemistry.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Adenine is a high affinity adenine receptor agonist (Ki = 18 nM at rat adenine receptor). It inhibits forskolin-stimulated cAMP formation in CHO cells transfected with the adenine receptor; also stimulates GTPγS binding.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Adenine monohydrochloride hemihydrate is a high affinity adenine receptor agonist (Ki = 18 nM at rat adenine receptor). It inhibits forskolin-stimulated cAMP formation in CHO cells transfected with the adenine receptor and also stimulates GTPγS binding (pEC50 values are 8.54 and 7.21 respectively).
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
0
Compound Sets
24
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NPC Screening Collection
Selleckchem Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
104
Molecular Weight
135.05
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
0
Ring Count
2
Aromatic Ring Count
2
cLogP
-0.06
TPSA
80.48
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.53
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Adenosine Receptor
Endogenous Metabolite
Adenine phosphoribosyltransferase
DNA/RNA Synthesis
ACACB, ACP1, APRT, MTAP, PECR, SRPK2
Primary Target
Adenine Receptors
MOA
AChR inhibitor
AChR
Agonist
protein synthesis stimulant
Pathway
GPCR/G protein
Metabolism
Neuroscience
Cell Cycle/Checkpoint
DNA Damage/DNA Repair
Cell Cycle/DNA Damage
Metabolic Enzyme/Protease
Therapeutic Class
Dietary supplement
Source data
