General
Preferred name
CINCHONIDINE
Synonyms
¦Á-Quinidine ()
L-Cinchonidine ()
α-Quinidine ()
(-)-Cinchonidine ()
Cinchonidine sulphate ()
CINCHONIDINE SULFATE ()
Cinchovatine- ()
.alpha.-quinidine ()
NSC-5364 ()
TCMDC-123934 ()
Cinchonidine sulphate anhydrous ()
Cinchonidine sulfate, anhydrous ()
Cinchonidine sulfate anhydrous ()
P&D ID
PD001559
CAS
485-71-2
524-61-8
Tags
available
drug candidate
Drug Status
investigational
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Cinchonidine (¦Á-Quinidine) is a cinchona alkaloid found in Cinchona officinalis and Gongronema latifolium. A building block used in asymmetric synthesis in organic chemistry. Weak inhibitor of serotonin transporter (SERT) with Kis of 330, 4.2, 36, 196, 15 ¦ÌM for dSERT, hSERT, hSERT I172M, hSERT S438T, hSERT Y95F, respectively. Antimalarial activities[1].
PRICE
29
DESCRIPTION
Cinchonidine is an alkaloid found in Cinchona officinalis. It is used in asymmetric synthesis in organic chemistry. It is a stereoisomer and pseudo-enantiomer of cinchonine. Cinchonidine is a weak inhibitor of serotonin transporter (SERT) with Kis of 330, 4.2, 36, 196, 15 μM for dSERT, hSERT, hSERT I172M, hSERT S438T, hSERT Y95F, respectively.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Cinchonidine is a cinchona alkaloid found in Cinchona officinalis and Gongronema latifolium. It is used in asymmetric synthesis in organic chemistry. It has antimalarial agent.
(Enamine Bioactive Compounds)
DESCRIPTION
Cinchonidine (L-Cinchonidine) is an alkaloid extracted from Cinchona officinalis. It is a pseudo-enantiomer and stereoisomer of cinchonine.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Cinchonidine sulphate is the sulfate form of cinchonidine, which is an alkaloid found in Cinchona officinalis and Gongronema latifolium. It is used in asymmetric synthesis in organic chemistry.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
9
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
Enamine Bioactive Compounds
MedChem Express Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
38
Molecular Weight
294.17
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
5
Aromatic Ring Count
2
cLogP
3.16
TPSA
36.36
Fraction CSP3
0.42
Chiral centers
5.0
Largest ring
6.0
QED
0.88
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Parasite
Serotonin Transporter
SERT
MOA
5-HT Receptor
P glycoprotein inhibitor
Pathway
GPCR/G protein
Microbiology/virology
Neuroscience
Anti-infection
Neuronal Signaling
Solubility
DMSO: 29 mg/mL (98.5 mM)<br/>Ethanol: 29 mg/mL (98.5 mM)<br/>Water: Insoluble
Soluble in DMSO, not in water
Source data
