General
Preferred name
HARMINE
Synonyms
telepathine hydrochloride ()
Harmine (hydrochloride) ()
Telepathine (hydrochloride) ()
telepathine ()
HARMINE HYDROCHLORIDE ()
7-methoxy-1-methyl-9H-pyrido[3,4-b]indole ()
P&D ID
PD001545
CAS
442-51-3
6028-02-0
122992-92-1
343-27-1
Tags
available
natural product
drug candidate
Drug indication
Discovery agent
diabetes mellitus
Drug Status
investigational
experimental
Max Phase
1.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Harmine is a plant-derived β-carboline alkaloid that has psychoactive activity. It has been reported as an inhibitor of dual specificity tyrosine phosphorylation regulated kinases of the Dyrk1 subfamily and monoamine oxidase A . Harmine has been tested in preclincal studies for antidepressant potential (GtoPdb)
DESCRIPTION Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM[1].
PRICE 29
DESCRIPTION Harmine (Telepathine) is an alkaloid isolated from seeds of Peganum harmala.
DESCRIPTION Harmine Hydrochloride (Telepathine Hydrochloride) is a natural DYRK inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM[1].
PRICE 29
DESCRIPTION Selective Skp2 inhibitor; suppresses E3 ligase activity (Tocris Bioactive Compound Library)
DESCRIPTION Inhibition of human MAOA; PUBCHEM_BIOASSAY: MLPCN Dyrk1A - CLK1 Selectivity Assay Measured in Biochemical System Using Plate Reader - 2124-05_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504442] (TargetMol Bioactive Compound Library)
DESCRIPTION Harmine hydrochloride (telepathine hydrochloride) is extracted from Peganum Harmala Genus. (TargetMol Bioactive Compound Library)
Cell lines
36
Organisms
6
Compound Sets
17
AdooQ Bioactive Compound Library
A17316
Cayman Chemical Bioactives
10010324
35146
ChEMBL Drugs
CHEMBL269538
CZ-OPENSCREEN Bioactive Library
DrugBank
DB07919
DrugMAP
DMPA5WD
Guide to Pharmacology
9352
Kinase Inhibitors (best-in-class)
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL269538
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
CHEMBL269538
MedChem Express Bioactive Compound Library
HY-N0737A
HY-N0737
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
harmine
harmine-hydrochloride
TargetMol Bioactive Compound Library
N036-0105
T2811
The Spectrum Collection
Tocris Bioactive Compound Library
5075
ZINC Tool Compounds
ZINC000018847046
External IDs
46
Properties
(calculated by RDKit )
Molecular Weight
212.09
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
3
cLogP
3.03
TPSA
37.91
Fraction CSP3
0.15
Chiral centers
0.0
Largest ring
6.0
QED
0.67
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Pathway
Cell Cycle/DNA Damage
Cell Cycle/Checkpoint
GPCR/G protein
Neuroscience
Tyrosine Kinase/Adaptors
Neuronal Signaling
Protein Tyrosine Kinase/RTK
Target
DYRK1
RAD51
5-HT Receptor
DYRK
DYRK1A
DYRK1B
DYRK2
GluR1
PPAR??MAO-A
5-HT Receptor,ADC Cytotoxin,DYRK,MAO
MAO,PPAR
Kinase group
CMGC
MOA
Inhibitor
CDK5 Inhibitors
Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 1A (DYRK1A) Inhibitors
CDK2 Inhibitors
Member status
virtual
Source data