General
Preferred name
HARMINE
Synonyms
telepathine hydrochloride ()
telepathine ()
HARMINE HYDROCHLORIDE ()
Harmine (hydrochloride) ()
Telepathine (hydrochloride) ()
Harmine HCl ()
P&D ID
PD001545
CAS
442-51-3
343-27-1
6028-02-0
122992-92-1
Tags
drug candidate
natural product
available
Drug indication
Discovery agent
Drug Status
experimental
investigational
Max Phase
0.5
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Harmine is a plant-derived β-carboline alkaloid that has psychoactive activity. It has been reported as an inhibitor of dual specificity tyrosine phosphorylation regulated kinases of the Dyrk1 subfamily and monoamine oxidase A . Harmine has been tested in preclincal studies for antidepressant potential (GtoPdb)
DESCRIPTION Selective Skp2 inhibitor; suppresses E3 ligase activity (Tocris Bioactive Compound Library)
Cell lines
33
Organisms
6
Compound Sets
16
AdooQ Bioactive Compound Library
A17316
Cayman Chemical Bioactives
10010324
35146
ChEMBL Drugs
CHEMBL269538
DrugBank
DB07919
DrugMAP
DMPA5WD
Guide to Pharmacology
9352
Kinase Inhibitors (best-in-class)
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL269538
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
CHEMBL269538
MedChem Express Bioactive Compound Library
HY-N0737A
HY-N0737
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
harmine
harmine-hydrochloride
TargetMol Bioactive Compound Library
T1711
T2811
The Spectrum Collection
Tocris Bioactive Compound Library
5075
ZINC Tool Compounds
ZINC000018847046
External IDs
45
Properties
(calculated by RDKit )
Molecular Weight
212.09
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
3
cLogP
3.03
TPSA
37.91
Fraction CSP3
0.15
Chiral centers
0.0
Largest ring
6.0
QED
0.67
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Pathway
Cell Cycle/DNA Damage
Neuroscience
Cell Cycle/Checkpoint
Tyrosine Kinase/Adaptors
Metabolism
GPCR/G protein
Neuronal Signaling
Protein Tyrosine Kinase/RTK
Target
DYRK1
RAD51
GluR1
DYRK1A
DYRK1B
DYRK2
MAO
PPAR??MAO-A
5-HT Receptor
5-HT Receptor,ADC Cytotoxin,DYRK,MAO
MAO,PPAR
Kinase group
CMGC
Primary Target
DYRK
MOA
Inhibitor
CDK5 Inhibitors
Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 1A (DYRK1A) Inhibitors
CDK2 Inhibitors
Member status
virtual
Source data