General
Preferred name
NORHARMANE
Synonyms
NORHARMAN ()
2-Azacarbazole ()
??-Carboline ()
2,9-Diazafluorene ()
¦Â-Carboline ()
β-Carboline ()
Norharman, ¦Â-Carboline ()
beta-carboline ()
norharman ()
P&D ID
PD001542
CAS
244-63-3
Tags
drug candidate
natural product
available
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION β-carboline is a harmane type compound which acts as an inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1) . (GtoPdb)
Cell lines
0
Organisms
2
Compound Sets
9
Cayman Chemical Bioactives
33845
20043
DrugMAP
DMKYQWG
Guide to Pharmacology
8222
MedChem Express Bioactive Compound Library
HY-W008566
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
norharmane
TargetMol Bioactive Compound Library
T4024
The Spectrum Collection
ZINC Tool Compounds
ZINC000000066039
External IDs
32
Properties
(calculated by RDKit )
Molecular Weight
168.07
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
3
Aromatic Ring Count
3
cLogP
2.72
TPSA
28.68
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.55
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
DNA Damage/DNA Repair
Metabolic Enzyme/Protease
Neuronal Signaling
Target
DNA
Endogenous Metabolite
Monoamine Oxidase
MAO
Member status
member
MOA
Indoleamine 2,3-dioxygenase Inhibitors
MAO-B Inhibitors
Source data