General
Preferred name
PIPERINE
Synonyms
1-Piperoylpiperidine ()
Bioperine ()
(2E,4E)-5-(1,3-dioxaindan-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one ()
(E/Z)-Piperine ()
(E/Z)-Bioperine ()
(E/Z)-1-Piperoylpiperidine ()
NSC-21727 ()
FEMA NO. 2909 ()
P&D ID
PD001540
CAS
94-62-2
7780-20-3
147030-08-8
Tags
available
drug candidate
Drug indication
Pain
Vitiligo
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Piperine is an alkaloid, can be isolated from pepper. Piperine can inhibit the activity of P-glycoprotein and CYP3A4. Piperine inhibits HeLa cells with an IC50 of 61.94¡À0.054 ¦Ìg/mL[1][2][3].
DESCRIPTION (E/Z)-Piperine ((E/Z)-Bioperine) is an alkaloid with a pungent property. (E/Z)-Piperine shows anti-inflammation, immunomodulatory and anti-cancer, antispasmodic and anti-secretory effects. (E/Z)-Piperine demonstrates significant neuroprotective effect in Alzheimer¡¯s disease and Parkinson¡¯s disease[1].
PRICE 29
DESCRIPTION Piperine activates transient receptor potential vanilloid type 1 receptor and modulates GABAA receptors. Piperine inhibits monoamine oxidases, also affects cytochrome P450 (CYP) isoforms. It has been used in trials studying the treatment of Multiple Myeloma and Deglutition Disorders. (Enamine Bioactive Compounds)
DESCRIPTION Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders. (TargetMol Bioactive Compound Library)
Cell lines
10
Organisms
3
Compound Sets
18
AdooQ Bioactive Compound Library
A10734
Cayman Chemical Bioactives
11750
ChEMBL Drugs
CHEMBL43185
Concise Guide to Pharmacology 2019/20
2489
Concise Guide to Pharmacology 2021/22
2489
Concise Guide to Pharmacology 2023/24
2489
Drug Repurposing Hub
DrugBank
DB12582
DrugMAP
DMYEAB1
Enamine Bioactive Compounds
EBC-04442
Guide to Pharmacology
2489
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL43185
MedChem Express Bioactive Compound Library
HY-N0144
HY-W230975
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
Piperine(1-Piperoylpiperidine)
TargetMol Bioactive Compound Library
T3002
The Spectrum Collection
External IDs
42
Properties
(calculated by RDKit )
Molecular Weight
285.14
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
1
cLogP
3.0
TPSA
38.77
Fraction CSP3
0.35
Chiral centers
0.0
Largest ring
6.0
QED
0.63
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Autophagy
Membrane Transporter/Ion Channel
Metabolism
Neuroscience
Metabolic Enzyme/Protease
Member status
member
MOA
ACAT Inhibitors
MAO-A Inhibitors
MAO-B Inhibitors
monoamine oxidase inhibitor
Target
MAOA, MAOB, TRPV1
Endogenous Metabolite
P-glycoprotein
Cytochrome P450
P450 (e.g. CYP17)
CYP3A4
P-gp (P-glycoprotein)
Source data