General
Preferred name
ESCULETIN
Synonyms
Aesculetin ()
Cichorigenin ()
Cichorigenin|Aesculetin ()
Cichorigenin, Aesculetin ()
P&D ID
PD001534
CAS
305-01-1
Tags
available
natural product
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Esculetin is an active ingredient extracted mainly from the bark of Fraxinus rhynchophylla. Esculetin inhibits platelet-derived growth factor (PDGF)-induced airway smooth muscle cells (ASMCs) phenotype switching through inhibition of PI3K/Akt pathway. Esculetin has antioxidant, antiinflammatory, and antitumor activities[1].
PRICE 29
DESCRIPTION Esculetin (Cichorigenin) is a coumarin derivative from various natural plant products with various biological and pharmaceutical properties including anti-edema, anti-inflammatory and anti-tumour effects. It inhibits lipoxygenases (LOs). (TargetMol Bioactive Compound Library)
Cell lines
4
Organisms
0
Compound Sets
7
Cayman Chemical Bioactives
19286
Concise Guide to Pharmacology 2021/22
5180
CZ-OPENSCREEN Bioactive Library
Guide to Pharmacology
5180
MedChem Express Bioactive Compound Library
HY-N0284
Selleckchem Bioactive Compound Library
esculetin
TargetMol Bioactive Compound Library
T2798
External IDs
35
Properties
(calculated by RDKit )
Molecular Weight
178.03
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
0
Ring Count
2
Aromatic Ring Count
2
cLogP
1.2
TPSA
70.67
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.47
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Akt
Lipoxygenase
PI3K
Pathway
Cytoskeletal Signaling
Metabolism
PI3K/Akt/mTOR signaling
PI3K/Akt/mTOR
Source data