General
Preferred name
FLUPHENAZINE DIHYDROCHLORIDE
Synonyms
FLUPHENAZINE HYDROCHLORIDE ()
Fluphenazine (HCl) ()
Prolixin ()
Fluphenazine (dihydrochloride) ()
NSC-179197 ()
Moditen ()
Anatensol ()
Fluphenazine HCl ()
SQUIBB 4918 ()
Fluphenazine dihydrochloride ()
Permitil ()
Dapotum ()
Fluphenazini hydrochloridum ()
P&D ID
PD001518
CAS
146-56-5
Tags
available
drug
nuisance
Drug Status
approved
Max Phase
4.0
Drug indication
Multiple myeloma
First approval
1959
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Fluphenazine dihydrochloride is a phenothiazine-class D1DR and D2DR inhibitor. It also inhibits Histamine H1 Receptor. (Enamine Bioactive Compounds)
DESCRIPTION Dopamine receptor antagonist; antipsychotic (LOPAC library)
DESCRIPTION Fluphenazine dihydrochloride (Prolixin) is an inhibitor of phenothiazine-class D1DR and D2DR; In studies, Fluphenazine can be used to probe the effects and metabolic process of this commonly used dopamine antagonist. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
2
Compound Sets
12
ChEMBL Approved Drugs
CHEMBL1448187
ChEMBL Drugs
CHEMBL1448187
CZ-OPENSCREEN Bioactive Library
Enamine Bioactive Compounds
EBC-07795
Enamine BioReference Compounds
LOPAC library
MedChem Express Bioactive Compound Library
HY-A0081
Nuisance compounds in cellular assays
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
fluphenazine-dihydrochloride
TargetMol Bioactive Compound Library
T0068
The Spectrum Collection
External IDs
22
Properties
(calculated by RDKit )
Molecular Weight
509.13
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
2
cLogP
5.15
TPSA
29.95
Fraction CSP3
0.45
Chiral centers
0.0
Largest ring
6.0
QED
0.58
Structural alerts
1
CAD
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Selectivity
D1/D2
Target
dopamine
Dopamine Receptor
SARS-CoV
Sodium Channel
Pathway
Anti-infection
GPCR/G protein
Membrane Transporter/Ion Channel
Neuronal Signaling
Neuroscience
Source data