General
Preferred name
DROPERIDOL
Synonyms
Dehydrobenzperidol ()
NSC 169874 ()
NSC 169874,Dehydrobenzperidol ()
NSC-169874 ()
Inapsine ()
Dridol ()
McN-JR-4749 ()
Droleptan ()
R-4749 ()
P&D ID
PD001512
CAS
548-73-2
Tags
natural product
drug
available
Approved by
FDA
First approval
1970
Drug Status
withdrawn
approved
vet_approved
Drug indication
Nausea
Antipsychotic
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Droperidol has sedative, tranquilising, and anti-nausea actions. (GtoPdb)
Cell lines
0
Organisms
1
Compound Sets
26
Axon Medchem Screening Library
1554
Cayman Chemical Bioactives
18884
ChEMBL Approved Drugs
CHEMBL1108
ChEMBL Drugs
CHEMBL1108
Drug Repurposing Hub
DrugBank
DB00450
DrugBank Approved Drugs
DB00450
DrugCentral
966
DrugCentral Approved Drugs
966
DrugMAP
DM0DXA8
DrugMAP Approved Drugs
DM0DXA8
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
7172
Ki Database
DROPERIDOL
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1108
MedChem Express Bioactive Compound Library
HY-B1240
NCATS Inxight Approved Drugs
O9U0F09D5X
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
droperidol
TargetMol Bioactive Compound Library
T0990
The Spectrum Collection
Withdrawn 2.0
w122
External IDs
35
Properties
(calculated by RDKit )
Molecular Weight
379.17
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
3
cLogP
3.68
TPSA
58.1
Fraction CSP3
0.27
Chiral centers
0.0
Largest ring
6.0
QED
0.66
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Target
D2
ADRA1A, DRD2, DRD3, DRD4, HTR2A
D2/a1 antagonist
Dopamine Receptor
Indication
nausea, vomiting
MOA
Dopamine Receptor antagonist
ATC
N05AD08
Toxicity type
cardiovascular
Therapeutic Class
Antipsychotic Agents
Source data