General
Preferred name
DROPERIDOL
Synonyms
NSC 169874 ()
Dehydrobenzperidol ()
NSC 169874,Dehydrobenzperidol ()
McN-JR-4749 ()
NSC-169874 ()
R-4749 ()
Droperidol component of innovar ()
Dridol ()
Inapsine ()
Droleptan ()
Droperiol ()
P&D ID
PD001512
CAS
548-73-2
Tags
available
drug
Approved by
FDA
First approval
1970
Drug indication
Nausea
Psychosis
Drug Status
vet_approved
approved
withdrawn
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Droperidol (Dehydrobenzperidol) is a butyrophenone pamine-2 receptor antagonist that inhibits the activation of GABA(A) and neuronal nicotinic receptors (nAChR), with IC50 values of 12.6 nM and 5.8 ¦ÌM. Droperidol has anesthetic and sedative properties[1][2].
DESCRIPTION Droperidol has sedative, tranquilising, and anti-nausea actions. (GtoPdb)
DESCRIPTION Droperidol is a dopamine-2 receptor antagonist. Droperidol is a butyrophenone, with anti-emetic, sedative and anti-anxiety properties. (Enamine Bioactive Compounds)
DESCRIPTION Droperidol (Dehydrobenzperidol) is a Dopamine-2 Receptor Antagonist. The mechanism of action of droperidol is as a Dopamine D2 Antagonist. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
27
Axon Medchem Screening Library
1554
Cayman Chemical Bioactives
18884
ChEMBL Approved Drugs
CHEMBL1108
ChEMBL Drugs
CHEMBL1108
Drug Repurposing Hub
DrugBank
DB00450
DrugBank Approved Drugs
DB00450
DrugCentral
966
DrugCentral Approved Drugs
966
DrugMAP
DM0DXA8
DrugMAP Approved Drugs
DM0DXA8
DrugMatrix
Enamine Bioactive Compounds
EBC-08486
Enamine BioReference Compounds
Guide to Pharmacology
7172
Ki Database
DROPERIDOL
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1108
MedChem Express Bioactive Compound Library
HY-B1240
NCATS Inxight Approved Drugs
O9U0F09D5X
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
droperidol
TargetMol Bioactive Compound Library
T0990
The Spectrum Collection
Withdrawn 2.0
w122
External IDs
36
Properties
(calculated by RDKit )
Molecular Weight
379.17
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
3
cLogP
3.68
TPSA
58.1
Fraction CSP3
0.27
Chiral centers
0.0
Largest ring
6.0
QED
0.66
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
D2
dopamine
ADRA1A, DRD2, DRD3, DRD4, HTR2A
D2/a1 antagonist
Dopamine Receptor
GABA Receptor
nAChR
Indication
nausea, vomiting
MOA
Dopamine Receptor antagonist
ATC
N05AD08
Toxicity type
cardiovascular
Therapeutic Class
Antipsychotic Agents
Pathway
GPCR/G protein
Membrane Transporter/Ion Channel
Neuronal Signaling
Neuroscience
Source data