General
Preferred name
FAMOTIDINE
Synonyms
MK-208 ()
YM 11170 ()
MK208 ()
PEPDINE ()
GANOR ()
AMFAMOX ()
YM-11170 ()
MUCLOX ()
Famotidine component of duexis ()
LECEDIL ()
PEPCID RPD ()
FAMOTIDINA ()
GASTROPEN ()
FAMOXAL ()
Gaster ()
FAMOSAN ()
Pepcidine ()
FAMOTIDINE PRESERVATIVE FREE ()
L 643341 ()
FAMODIL ()
PEPCIDAC ()
Pepcid ac (geltab) ()
PEPCID PRESERVATIVE FREE ()
FAMOTIDINE PRESERVATIVE FREE (PHARMACY BULK) ()
Famotidine component of pepcid complete ()
PEPCID ()
PEPCID AC ()
MOTIAX ()
FADUL ()
PEPDUL ()
FLUXID ()
GASTRIDIN ()
NSC-757810 ()
Famotidine-13C-d3 ()
FAMOTIDINE COMPONENT OF DUEXIS ()
FAMOTIDINE COMPONENT OF PEPCID COMPLETE ()
GASTER ()
PEPCIDINE ()
P&D ID
PD001511
CAS
76824-35-6
2744683-81-4
Tags
available
drug
biased GPCR ligand
Approved by
FDA
First approval
1986
Drug indication
Peptic ulcer
Movement disorder
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCPRITION A competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.
DESCRIPTION Famotidine is a histamine H2 receptor antagonist. The drug is poorly soluble in the low pH of the stomach so suffers from poor bioavailability. Low dose (10-20 mg) famotidine is available over-the-counter in some countries. Marketing of a combination of famotidine with antacids magnesium hydroxide and calcium carbonate (Pepcidtwo®) has been officially discontinued in the UK (2015). (GtoPdb)
DESCRIPTION Famotidine (MK-208) is a competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.
PRICE 29
DESCRIPTION Potent, selective and competitive non-peptide NPY Y2 receptor antagonist; active in vivo (Tocris Bioactive Compound Library)
DESCRIPTION H2 Histamine receptor antagonist (LOPAC library)
DESCRIPTION Famotidine is a histamine H2 receptor antagonist. It is used to treat duodenal ulcers, benign gastric ulcers, GERD, and Zollinger-Ellison syndrome. (Enamine Bioactive Compounds)
DESCRIPTION Famotidine (MK-208) is a propanimidamide and histamine H2-receptor antagonist with antacid activity. As a competitive inhibitor of histamine H2-receptors on the basolateral membrane of parietal cells, famotidine reduces basal and nocturnal gastric acid secretion, thereby decreasing gastric volume, acidity, and the amount of gastric acid released in response to various stimuli. (TargetMol Bioactive Compound Library)
Compound Sets
32
BiasDB
Famotidine
Cayman Chemical Bioactives
23828
31493
ChEMBL Approved Drugs
CHEMBL902
ChEMBL Drugs
CHEMBL902
Concise Guide to Pharmacology 2023/24
7074
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00927
DrugBank Approved Drugs
DB00927
DrugCentral
1129
DrugCentral Approved Drugs
1129
DrugMAP
DMRL3AB
DrugMAP Approved Drugs
DMRL3AB
DrugMatrix
Enamine Bioactive Compounds
EBC-26642
Enamine BioReference Compounds
EUbOPEN Chemogenomics Library
EUB0000812
Guide to Pharmacology
7074
Ki Database
YM 11170
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL902
MedChem Express Bioactive Compound Library
HY-B0377
NCATS Inxight Approved Drugs
5QZO15J2Z8
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
famotidine-pepcid
TargetMol Bioactive Compound Library
T1627
The Spectrum Collection
Tocris Bioactive Compound Library
7290
ZINC Tool Compounds
ZINC000001530636
External IDs
71
Properties
(calculated by RDKit )
Molecular Weight
337.04
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
4
Rotatable Bonds
7
Ring Count
1
Aromatic Ring Count
1
cLogP
-0.77
TPSA
175.83
Fraction CSP3
0.38
Chiral centers
0.0
Largest ring
5.0
QED
0.29
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Selectivity
H2
Pathway
GPCR/G protein
Immunology/Inflammation
Neuroscience
Neuronal Signaling
Primary Target
Histamine H2 Receptors
MOA
Inverse Agonist
Histamine Receptor antagonist
Indication
heartburn
Target
HRH2
Histamine Receptor
H2 receptor
Therapeutic Class
Antiulcer Agents
Recommended Cell Concentration
None
Source data