General
Preferred name
ETODOLAC
Synonyms
Ultradol ()
AY-24236 ()
Etodolic acid ()
Lodine ()
Edolan ()
Eccoxolac ()
Lodin xl ()
(rs)-etodolic acid ()
Etolyn ()
AY-24,236 ()
NIH-9918 ()
Tedolan ()
Etopan XL ()
Ramodar ()
Zedolac ()
Lodine Xl ()
Etodolaco ()
NSC-282126 ()
Napilac ()
AY-24-236 ()
Ebretin ()
Flancox ()
Lodine Sr ()
P&D ID
PD001509
CAS
41340-25-4
Tags
available
drug
Approved by
FDA
First approval
1991
Drug indication
Pain
rheumatic disease
Drug Status
vet_approved
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Etodolac (AY-24236) is a non-steroidal anti-inflammatory compound that is a non-selective inhibitor of COX (IC50=53.5 nM)
PRICE
29
DESCRIPTION
Etodolac is a nonsteroidal anti-inflammatory drug (NSAID).
(GtoPdb)
DESCRIPTION
Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis.
(Enamine Bioactive Compounds)
DESCRIPTION
Non-steroidal anti-inflammatory drug (NSAID)
(LOPAC library)
DESCRIPTION
Etodolac (AY-24236) inhibits the activity of cyclooxygenase I and II, thereby preventing the formation of prostaglandin which is involved in the induction of pain, fever, and inflammation. Etodolac is a pyranocarboxylic acid and non-steroidal anti-inflammatory drug (NSAID) with antipyretic and analgesic activities. It also inhibits platelet aggregation by blocking platelet cyclooxygenase and the subsequent formation of thromboxane A2.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
25
Axon Medchem Screening Library
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
Ki Database
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
38
Molecular Weight
287.15
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
2
cLogP
3.38
TPSA
62.32
Fraction CSP3
0.47
Chiral centers
1.0
Largest ring
6.0
QED
0.91
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
COX
Target
RXR-alpha
COX-2 inhibitor
Therapeutic Class
Analgesics
Pathway
Immunology/Inflammation
Metabolism
Neuroscience
Source data
