General
Preferred name
FENBUFEN
Synonyms
CL-82204 ()
Lederfen ()
Lederfen, CL-82204 ()
Lederfen CP ()
Fenbuzip 450 ()
Lederfen 450 ()
CL 82,204 ()
NSC-757812 ()
Cinopal ()
Lederfen F ()
Fenbuzip 300 ()
Fenbufene ()
P&D ID
PD001507
CAS
36330-85-5
Tags
available
drug
Drug indication
Arthritis
rheumatic disease
Drug Status
investigational
approved
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with analgetic and antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC50s of 3.9 ¦ÌM and 8.1 ¦ÌM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor[1][2][3][4][5].
PRICE 29
DESCRIPTION Fenbufen is a non-steroidal anti-inflammatory synthetic active reagent. (BOC Sciences Bioactive Compounds)
DESCRIPTION Fenbufen is a non-steroidal anti-inflammatory drug and a prodrug form of 4-biphenylacetic acid. Fenbufen was previously used in the treatment of osteoarthritis and inflammatory pain. (Enamine Bioactive Compounds)
DESCRIPTION Fenbufen (Lederfen) is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. It can also be used to relieve backaches, sprains, and fractures. Fenbufen is available as a capsule or tablet sold with the brand names Cepal, Cinopal, Cybufen, Lederfen, and Reugast. Fenbufen acts by preventing cyclooxygenase from producing prostaglandins which can cause inflammation. (TargetMol Bioactive Compound Library)
Compound Sets
20
BOC Sciences Bioactive Compounds
fenbufen-cas-36330-85-5-343439
Cayman Chemical Bioactives
28851
ChEMBL Drugs
CHEMBL277522
Drug Repurposing Hub
DrugBank
DB08981
DrugBank Approved Drugs
DB08981
DrugCentral
1145
DrugCentral Approved Drugs
1145
DrugMAP
DMXGDFK
DrugMAP Approved Drugs
DMXGDFK
DrugMatrix
Enamine Bioactive Compounds
EBC-02045
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
HY-B1138
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
fenbufen
TargetMol Bioactive Compound Library
T0859
The Spectrum Collection
External IDs
32
Properties
(calculated by RDKit )
Molecular Weight
254.09
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
2
cLogP
3.4
TPSA
54.37
Fraction CSP3
0.12
Chiral centers
0.0
Largest ring
6.0
QED
0.83
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
ATP systhesis
Caspase
COX
PTGS1, PTGS2
Indication
pain relief
MOA
cyclooxygenase inhibitor
Pathway
Apoptosis
Immunology/Inflammation
Membrane Transporter/Ion Channel
Neuroscience
Proteases/Proteasome
Solubility
Soluble in DMSO
Source data