General
Preferred name
FENOPROFEN
Synonyms
Fenoprofen (Calcium hydrate) ()
Fenoprofen (Calcium) ()
Fenoprofen calcium salt dihydrate ()
Nalgesic ()
Nalfon ()
FENOPROFEN CALCIUM ()
Fenoprofen calcium dihydrate ()
LILLY-53858 (Calcium hydrate) ()
LILLY-53858 ()
Fenoprofen calcium salt dihydrate,Feprona dihydrate,Progesic dihydrate ()
Fenoprofen calcium hydrate ()
Fenoprofen (calcium salt hydrate) ()
Fenoprofeno ()
Fenoprofene ()
53858 ()
NSC-757813 ()
Progesic ()
fenoprofen ()
Fepron ()
Feprona ()
Fenopron ()
69323 ()
Fenoprofen-13C6Â (sodium salt hydrate) ()
P&D ID
PD001505
CAS
31879-05-7
34597-40-5
56367-29-4
95907-05-4
29679-58-1
53746-45-5
71720-56-4
2687960-29-6
Tags
available
drug
Approved by
FDA
First approval
1976
Drug indication
rheumatic disease
Rheumatoid arthritis
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Fenoprofen isa nonsteroidal anti-inflammatory drug, which is pharmacologically similar to aspirin, with similar anti-inflammatory analgesic and antipyretic actions.
(GtoPdb)
DESCRIPTION
Fenoprofen (LILLY-53858) is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen also increases ERK1/2 activation in HEK293T cells. Fenoprofen has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis[1][2].
PRICE
29
PRICE
29
PRICE
29
DESCRIPTION
Fenoprofen (LILLY-53858) Calcium hydrate is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen Calcium hydrate is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen Calcium hydrate also increases ERK1/2 activation in HEK293T cells. Fenoprofen Calcium hydrate has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis[1][2].
DESCRIPTION
Fenoprofen (LILLY-5385) is a non-steroidal anti-inflammatory compound and a modifier enhancer of the melanocortin receptor, which increases ERK1/2 activation, inhibits biofilm formation, and alters biofilm structure, and is used in the treatment of acute pain and chronic arthritis.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Fenoprofen is an anti-inflammatory analgesic agent.
(Enamine Bioactive Compounds)
DESCRIPTION
Fenoprofen calcium is a propionic acid derivative that is used as a non-steroidal anti-inflammatory agent.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Potent and selective negative allosteric modulator of mGlu2 receptors
(Tocris Bioactive Compound Library)
DESCRIPTION
Fenoprofen Calcium is a nonsteroidal, anti-inflammatory, and antiarthritic agent.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Fenoprofen calcium hydrate is a non-steroidal anti-inflammatory drug (NSAID).
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
34
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
Ki Database
LSP-MoA library (Laboratory of Systems Pharmacology)
NCATS Inxight Approved Drugs
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
93
Molecular Weight
242.09
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
3.67
TPSA
46.53
Fraction CSP3
0.13
Chiral centers
1.0
Largest ring
6.0
QED
0.89
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
COX
cyclooxygenase
COX-1
COX-2
Melanocortin Receptor
Apoptosis
ERK
Immunology & Inflammation related
Pathway
Immunology/Inflammation
Neuroscience
GPCR/G protein
MAPK/ERK Pathway
Neuronal Signaling
Stem Cell/Wnt
MOA
cyclooxygenase inhibitor
Modulator
Primary Target
Melanocortin (MC) Receptors
Therapeutic Class
Antiinflammatory Agents
Source data
