General
Preferred name
FLUFENAMIC ACID
Synonyms
Nichisedan ()
Achless ()
Arlef ()
flufenamate ()
flufenamic-acid ()
CN-27554 ()
NSC-219007 ()
INF-1837 ()
CN-27,554 ()
CI 440 ()
Meralen ()
NSC-82699 ()
CI-440 ()
Flufenamic Acid ()
P&D ID
PD001503
CAS
530-78-9
16449-54-0
Tags
drug candidate
natural product
drug
available
First approval
1963
Drug Status
approved
Drug indication
Discovery agent
Anti-Inflammatory
Dysmenorrhea
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION A non-selective cyclooxygenase inhibitor; NSAID. (GtoPdb)
DESCRIPTION Chloride channel blocker; TRPV1 modulator; RAD51 recombinase inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION Flufenamic Acid is an anti-inflammatory agent, and also acts as an ion channel modulator. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
33
AdooQ Bioactive Compound Library
A13333
BOC Sciences Bioactive Compounds
flufenamic-acid-cas-530-78-9-item-84-70665
Cayman Chemical Bioactives
21447
ChEMBL Approved Drugs
CHEMBL23588
ChEMBL Drugs
CHEMBL23588
Concise Guide to Pharmacology 2017/18
2447
4191
Concise Guide to Pharmacology 2019/20
2447
4191
Concise Guide to Pharmacology 2021/22
2447
4191
Concise Guide to Pharmacology 2023/24
2447
4191
Drug Repurposing Hub
DrugBank
DB02266
DrugBank Approved Drugs
DB02266
DrugCentral
1193
DrugCentral Approved Drugs
1193
DrugMAP
DMC8VNH
DMN8AP0
DrugMAP Approved Drugs
DMC8VNH
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101118
Guide to Pharmacology
2447
4191
IPPI - DB
1911
JUMP-Target 1 Compound Set
3371
Ki Database
Flufenamate
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL23588
MedChem Express Bioactive Compound Library
HY-B1221
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
flufenamic-acid
TargetMol Bioactive Compound Library
T0858
The Spectrum Collection
Tocris Bioactive Compound Library
4522
ZINC Tool Compounds
ZINC000000086535
External IDs
49
Properties
(calculated by RDKit )
Molecular Weight
281.07
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
4.15
TPSA
49.33
Fraction CSP3
0.07
Chiral centers
0.0
Largest ring
6.0
QED
0.89
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Immunology/Inflammation
Neuroscience
Anti-infection
Epigenetics
Membrane Transporter/Ion Channel
Neuronal Signaling
PI3K/Akt/mTOR
Target
COX
AKR1C3, ANO1, AR, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, GJE1, PANX1, PANX2, PANX3, PKD2L1, PTGS1, PTGS2, TRPC5, TRPM2, TRPM5
GJB4
AMPK
Calcium Channel
Chloride channel
Parasite
Potassium Channel
Immunology & Inflammation related
Primary Target
Calcium-activated Chloride Channels
MOA
Blocker
chloride channel blocker
Source data