General
Preferred name
SULFAPHENAZOLE
Synonyms
Depocid ()
Depotsulfonamide ()
Plisulfan ()
Raziosulfa ()
Sulfaphenazole ()
Depocid, Depotsulfonamide, Plisulfan, Raziosulfa ()
Sulfabid ()
Sulfafenazol ()
Sulphaphenazole ()
NSC-757859 ()
Orisulf ()
P&D ID
PD001500
CAS
526-08-9
Tags
natural product
drug
available
Approved by
FDA
First approval
1982
1974
Drug Status
approved
withdrawn
Drug indication
Bacterial infection
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Sulfaphenazole is a long-acting sulfonamide antibacterial. (GtoPdb)
DESCRIPTION Antibacterial; inhibitor of cytochrome P4502C enzymes (LOPAC library)
Cell lines
0
Organisms
1
Compound Sets
24
Axon Medchem Screening Library
2922
Cayman Chemical Bioactives
14844
ChEMBL Approved Drugs
CHEMBL1109
ChEMBL Drugs
CHEMBL1109
Concise Guide to Pharmacology 2021/22
11352
Drug Repurposing Hub
DrugBank
DB06729
DrugBank Approved Drugs
DB06729
DrugCentral
2523
DrugCentral Approved Drugs
2523
DrugMAP
DMFNAEM
DrugMAP Approved Drugs
DMFNAEM
DrugMatrix
Guide to Pharmacology
11352
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1109
MedChem Express Bioactive Compound Library
HY-B1218
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
sulfaphenazole
TargetMol Bioactive Compound Library
T4567
The Spectrum Collection
Withdrawn 2.0
1354
External IDs
28
Properties
(calculated by RDKit )
Molecular Weight
314.08
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
3
cLogP
2.26
TPSA
90.01
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.72
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Cytochrome P4502C
Pathway
Metabolism
Anti-infection
Apoptosis
Metabolic Enzyme/Protease
Target
CYP2C9
DHPS
CYP2C9 inhibitor
antibiotic
Bacterial
Cytochrome P450
Necroptosis
P450 (e.g. CYP17)
MOA
P450 inhibitor
dihydropteroate synthetase inhibitor
Indication
urinary tract infections
ATC
J01ED08
Therapeutic Class
Antiinfective Agents
Source data