General
Preferred name
SULPIRIDE
Synonyms
(RS)-(±)-Sulpiride ()
(±)-Sulpiride ()
LEVOSULPIRIDE ()
Dolmatil ()
Dobren ()
Sulpyrid ()
Aiglonyl ()
Dogmatil ()
SULPIRIDE,(+) ()
SULPIRIDE,(-) ()
Sulpiride-R ()
(RS)-(+/-)-Sulpiride ()
Dolmatil, Dobren, Sulpyrid, Aiglonyl, Dogmatil ()
Dogmatyl ()
NSC-757850 ()
RD-1403 ()
N05AL01 ()
P&D ID
PD001493
CAS
15676-16-1
Tags
natural product
drug
available
First approval
1972
Drug Status
investigational
approved
Drug indication
Schizophrenia
Antidepressant
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
TOXICITY
Although sulpiride has a low potential for causing acute toxicity, substantial amounts of the drug may cause severe but reversible dystonic crises, which may be associated with torticollis, protrusion of the tongue, and/or trism. Oversedation, coma, and classical symptoms typical of severe Parkinson's Disease may also be observed.
DESCRIPTION
The approved drug sulpiride is an enantiomeric mixture of (+)-sulpiride and (-)-sulpiride. We show the non-isomeric structure to represent the mixture.
(GtoPdb)
DESCRIPTION
D2 dopamine receptor antagonist; antipsychotic
(LOPAC library)
DESCRIPTION
Standard selective D2-like antagonist
(Tocriscreen Plus)
DESCRIPTION
Standard selective D2-like antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Standard selective D2-like antagonist
(Tocriscreen Total)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
26
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
Ki Database
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
43
Molecular Weight
341.14
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
1
cLogP
0.56
TPSA
101.73
Fraction CSP3
0.53
Chiral centers
1.0
Largest ring
6.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Selectivity
D2
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Target
dopamine
Dopamine Receptor
Primary Target
Non-selective Dopamine
MOA
Antagonist
Dopamine D2 Antagonists
Carbonic Anhydrase Type VII Inhibitors
Member status
virtual
Therapeutic Class
Antipsychotic Agents
Source data
