General
Preferred name
SPIPERONE
Synonyms
SPIPERONE HYDROCHLORIDE ()
Spiroperidol ()
Spiropitan ()
[3H]spiperone ()
[3H]spiperone ()
R 5147 ()
R-5147 ()
NSC-170983 ()
P&D ID
PD001491
CAS
749-02-0
2022-29-9
Tags
natural product
drug
available
First approval
1969
Drug indication
Discovery agent
Antipsychotic
Drug Status
investigational
approved
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Selective D2 dopamine receptor antagonist.
(LOPAC library)
DESCRIPTION
5-HT2A antagonist. Also D2-like antagonist
(Tocriscreen Total)
DESCRIPTION
Spiperone hydrochloride is a 5-HT2A and selective dopamine D2 receptor antagonist (Ki = 0.06, 0.6, 0.08, ~ 350, ~ 3500 nM for D2, D3, D4, D1 and D5 receptors, respectively) used as an antipsychotic. It also acts as an activator of calcium-activated chloride channels (EC50 = 9.3 µM).
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
4
Compound Sets
23
BOC Sciences Bioactive Compounds
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
Ki Database
LOPAC library
MedChem Express Bioactive Compound Library
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
37
Molecular Weight
395.2
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
2
cLogP
3.22
TPSA
52.65
Fraction CSP3
0.39
Chiral centers
0.0
Largest ring
6.0
QED
0.76
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
D2
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Target
dopamine
ADRA1A, ADRA1B, ADRA1D, DRD1, DRD2, DRD3, DRD4, DRD5, HTR1A, HTR1D, HTR2A, HTR2B, HTR2C, HTR6, HTR7
5-HT Receptor
Dopamine Receptor
Indication
schizophrenia
MOA
Dopamine Receptor antagonist
Source data
