General
Preferred name
OROTIC ACID
Synonyms
Vitamin B13 ()
6-Carboxyuracil ()
2,4-dioxo-1H-pyrimidine-6-carboxylic acid hydrate ()
Orotic Acid Monohydrate ()
Orotic acid (6-Carboxyuracil), 6-Carboxyuracil, Orodin, Oropur, Orotonin, Orotonsan ()
Zinc orotate ()
Orotate ()
2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid hydrate ()
Orotic acid (6-Carboxyuracil) ()
Oropur ()
Orotyl ()
Animal galactose factor ()
Whey factor ()
NSC-9791 ()
P&D ID
PD001471
CAS
68460-00-4
60388-02-5
68399-76-8
65-86-1
73-97-2
50887-69-9
Tags
drug candidate
natural product
drug
available
Drug indication
Discovery agent
Drug Status
experimental
investigational
approved
Max Phase
Phase 2
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Orotic acid has been assigned an INN in its own right and is also a component of the INN-assigned compound orazamide.
(GtoPdb)
DESCRIPTION
Orotic acid is a heterocyclic compound and an acid. It is manufactured in the body via a mitochondrial enzyme, dihydroorotate dehydrogenase, or a cytoplasmic enzyme of pyrimidine synthesis pathway.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
21
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugCentral
DrugCentral Approved Drugs
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
72
Molecular Weight
156.02
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
1
cLogP
-1.24
TPSA
103.02
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.47
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolism
Cell Cycle/DNA Damage
Metabolic Enzyme/Protease
Target
DHOase
Apoptosis
DHODH
Endogenous Metabolite
Nucleoside antimetabolite/analog
MOA
Dehydrogenase
Source data
