General
Preferred name
FIROCOXIB
Synonyms
ML 1785713 ()
Firocoxib (ML 1785713) ()
ML-1,785,713 ()
Firocoxib (ema epar: veterinary) ()
Previcox ()
Coxatab ()
Librens ()
Equioxx ()
ML-1785713 ()
NSC-758895 ()
P&D ID
PD001470
CAS
189954-96-9
Tags
available
drug
Approved by
FDA
Drug indication
Discovery agent
Drug Status
vet_approved
approved
experimental
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Firocoxib (ML 1785713) is a potent, selective and orally active COX-2 inhibitor with an IC50 of 0.13 ¦ÌM. Firocoxib shows 58-fold more selective for COX-2 than COX-1 (IC50 of 7.5 ¦ÌM). Firocoxib has anti-inflammatory effects[1].
PRICE 82
DESCRIPTION Firocoxib (ML 1785713) is a selective non-steroidal inhibitor of cyclooxygenase-2 (COX-2) with an IC50 of 0.13 ??M, used for its anti-inflammatory properties in dogs and horses.
DESCRIPTION Firocoxib (ML 1785713) is a selective non-steroidal inhibitor of cyclooxygenase-2 (COX-2) with an IC50 of 0.13 μM, used for its anti-inflammatory properties in dogs and horses. (TargetMol Bioactive Compound Library)
Compound Sets
12
Cayman Chemical Bioactives
28286
ChEMBL Drugs
CHEMBL69998
Drug Repurposing Hub
DrugBank
DB09217
DrugBank Approved Drugs
DB09217
DrugCentral
5542
DrugMAP
DMP6GNY
MedChem Express Bioactive Compound Library
HY-14670
ReFrame library
Selleckchem Bioactive Compound Library
firocoxib
TargetMol Bioactive Compound Library
T7596
The Spectrum Collection
External IDs
27
Properties
(calculated by RDKit )
Molecular Weight
336.1
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
0
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
1
cLogP
2.56
TPSA
69.67
Fraction CSP3
0.47
Chiral centers
0.0
Largest ring
6.0
QED
0.77
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
COX
COX-2
PTGS2
Indication
osteoarthritis
MOA
cyclooxygenase inhibitor
Pathway
Immunology/Inflammation
Neuroscience
Source data