General
Preferred name
TIOGUANINE
Synonyms
THIOGUANINE ()
Thioguanine£»2-Amino-6-purinethiol ()
6-TG ()
2-Amino-6-purinethiol ()
2-Amino-6-mercaptopurine ()
6-Thioguanine ()
NSC 752,6-Thioguanine, 2-Amino-6-purinethiol ()
Thioguanine (NSC 752) ()
Thioguanine6-ThioguanineLanvisTioguanine6-Mercaptoguanine2-Aminopurine-6-thiol2-Amino-6-mercaptopurineTioguaninTG2-Amino-6-purinethiol ()
Thioguanine, anhydrous ()
Tioguanine ()
NSC-76504 ()
Thioguanine anhydrous ()
Thioguanine hemihydrate ()
Tabloid ()
Lanvis ()
NSC-752 ()
Tioguanina ()
Tioguanine hemihydrate ()
Thioguanin ()
P&D ID
PD001469
CAS
154-42-7
5580-03-0
Tags
available
prodrug
covalent binder
drug
Approved by
FDA
First approval
1966
Drug indication
Severe acute respiratory syndrome (SARS)
Acute myeloid leukaemia
Middle East Respiratory Syndrome (MERS)
non-Hodgkins lymphoma
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Inhibits inosine-5'-monophosphate dehydrogenase 1.
(GtoPdb)
DESCRIPTION
6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC50s of 25 ¦ÌM and 40 ¦ÌM for Plpros and recombinant human USP2, respectively.
PRICE
29
DESCRIPTION
MRP inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
Thioguanine incorporation alters the DNA cleavage induced by topoisomerase II in the presence and absence of etoposide
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Tioguanine is a purine analogue antineoplastic agent used for the induction of remission, and for remission consolidation in patients with acute nonlymphocytic anemias.
(Enamine Bioactive Compounds)
DESCRIPTION
6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
65
Organisms
3
Compound Sets
29
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
CovBinderInPDB
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
JUMP-Target 1 Compound Set
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NIH Approved Oncology Drugs
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
68
Molecular Weight
167.03
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
0
Ring Count
2
Aromatic Ring Count
2
cLogP
0.22
TPSA
80.48
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.39
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Immunosuppressants
Target
IMPDH1, IMPDH2
Purine analog
IMPDH1
Deubiquitinase
DNA Methyltransferase
Endogenous Metabolite
SARS-CoV
DNA methyltransferase (DNMT)
DNMT1
USP2
Indication
acute myeloid leukemia (AML)
MOA
purine antagonist
Pathway
Apoptosis
Autophagy
Cell Cycle/Checkpoint
Chromatin/Epigenetic
DNA Damage/DNA Repair
Metabolism
Microbiology/virology
Ubiquitination
Anti-infection
Cell Cycle/DNA Damage
Epigenetics
Metabolic Enzyme/Protease
Therapeutic Class
Anticancer Agents
Antiviral Agents
Solubility
In Vitro:<br/>DMSO : 10 mg/mL(59.81 mM
Need ultrasonic and warming)<br/>In Vivo:<br/>1.Add each solvent one by one:10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline<br/>Solubility: ≥ 1.67 mg/mL (9.99 mM)
Clear solution
Source data
