General
Preferred name
CIPROFIBRATE
Synonyms
Ciprofibrate D6 ()
Win35833 ()
Win-35833 ()
Ciprofibrato ()
WIN 35833 ()
Modalim ()
NSC-759617 ()
Ciprofibrate-d6 ()
P&D ID
PD001436
CAS
52214-84-3
2070015-05-1
Tags
available
drug
Approved by
MHRA
First approval
1985
2009
Drug indication
Hyperlipoproteinemia
Cardiovascular disease
Drug Status
approved
withdrawn
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Ciprofibrate is a PPARĪ± agonist. (GtoPdb)
DESCRIPTION Ciprofibrate (Win35833) is a potent peroxisome proliferator and increases the phosphorylation level of the PPARalpha[1]. Ciprofibrate acts as an orally active hypolipidaemic agent and can be used for the research of primary hyperlipidaemias[2].
PRICE 29
DESCRIPTION Peroxizome proliferator;specific ligand for the nuclear peroxisome proliferator-activated receptor alpha (PPARalpha) (LOPAC library)
DESCRIPTION Ciprofibrate (Win35833) is a fibrate derivative with antilipidemic activity. (TargetMol Bioactive Compound Library)
Compound Sets
24
AdooQ Bioactive Compound Library
A11727
Cayman Chemical Bioactives
18515
33917
ChEMBL Approved Drugs
CHEMBL557555
ChEMBL Drugs
CHEMBL557555
CZ-OPENSCREEN Bioactive Library
DrugBank
DB09064
DrugBank Approved Drugs
DB09064
DrugCentral
658
DrugCentral Approved Drugs
658
DrugMAP
DMGC5DB
DrugMAP Approved Drugs
DMGC5DB
DrugMatrix
Guide to Pharmacology
3438
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL557555
MedChem Express Bioactive Compound Library
HY-B0664
NPC Screening Collection
NURSA ligand set
nursa/index.jsf?doi=10.1621%2FZF1ZNH8T48
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
ciprofibrate
TargetMol Bioactive Compound Library
T1264
The Spectrum Collection
Withdrawn 2.0
w195
External IDs
34
Properties
(calculated by RDKit )
Molecular Weight
288.03
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
1
cLogP
3.59
TPSA
46.53
Fraction CSP3
0.46
Chiral centers
1.0
Largest ring
6.0
QED
0.86
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
PPAR-alpha
Target
PPAR
Pathway
Cell Cycle/DNA Damage
DNA Damage/DNA Repair
Metabolism
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
ATC
C10AB08
Toxicity type
muscular
Therapeutic Class
Anticancer Agents
Source data