General
Preferred name
MESNA
Synonyms
Mesnum ()
Sodium 2-mercaptoethanesulfonate ()
Mesnex ()
Uromitexan ()
Mitexan ()
Coenzyme M Sodium ()
NSC-113891 ()
D 7093 ()
Coenzyme m sodium salt ()
D-7093 ()
Mistabron ()
Mesna ()
Mesna ()
P&D ID
PD001432
CAS
19767-45-4
3375-50-6
Tags
natural product
drug
available
Drug Status
approved
Max Phase
Phase 4
Drug indication
Detoxifying Agent
First approval
1988
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Mesna is converted to a free thiol compound in the kidney, where it binds to and inactivates acrolein and other urotoxic metabolites of ifosfamide and cyclophosphamide, thereby reducing their toxic effects on the urinary tract during urinary excretion.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
13
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
DrugMatrix
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
NIH Clinical Collections (NCC)
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
22
Molecular Weight
163.96
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
0
Aromatic Ring Count
0
cLogP
-3.53
TPSA
57.2
Fraction CSP3
1.0
Chiral centers
0.0
Largest ring
0.0
QED
0.26
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Chemoprotective agent
Source data
