General
Preferred name
MESNA
Synonyms
Mitexan ()
Uromitexan ()
Mesnum ()
Mesnex ()
Coenzyme M Sodium ()
Sodium 2-mercaptoethanesulfonate ()
NSC-113891 ()
D-7093 ()
Coenzyme m sodium salt ()
D 7093 ()
Mistabron ()
Mesna ()
Mesna ()
P&D ID
PD001432
CAS
19767-45-4
3375-50-6
Tags
available
drug
Drug Status
approved
Max Phase
4.0
Drug indication
Chronic kidney disease
First approval
1988
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Mesna (Sodium 2-mercaptoethanesulfonate) is an antioxidant which has cytoprotective effects. Mesna is widely used as a systemic protective agent against chemotherapy toxicity. Mesna is also used to reduce hemorrhagic cystitis induced by cyclophosphamide[1][2].
PRICE 29
DESCRIPTION Mesna is converted to a free thiol compound in the kidney, where it binds to and inactivates acrolein and other urotoxic metabolites of ifosfamide and cyclophosphamide, thereby reducing their toxic effects on the urinary tract during urinary excretion. (BOC Sciences Bioactive Compounds)
DESCRIPTION Sodium 2-mercaptoethanesulfonate (Uromitexan) is a sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from antineoplastic agents, such as ifosfamide or cyclophosphamide. (TargetMol Bioactive Compound Library)
Compound Sets
13
Axon Medchem Screening Library
3246
BOC Sciences Bioactive Compounds
mesna-cas-19767-45-4-item-84-62194
Cayman Chemical Bioactives
21238
ChEMBL Approved Drugs
CHEMBL975
ChEMBL Drugs
CHEMBL975
DrugMatrix
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
HY-13679
NIH Clinical Collections (NCC)
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
Mesna(Uromitexan)
TargetMol Bioactive Compound Library
T1414
The Spectrum Collection
External IDs
191
Properties
(calculated by RDKit )
Molecular Weight
163.96
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
0
Aromatic Ring Count
0
cLogP
-3.53
TPSA
57.2
Fraction CSP3
1.0
Chiral centers
0.0
Largest ring
0.0
QED
0.26
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Chemoprotective agent
Glutathione Peroxidase
Pathway
Apoptosis
Metabolic Enzyme/Protease
Source data