General
Preferred name
NIFLUMIC ACID
Synonyms
Nifluril ()
Forenol ()
Landruma ()
niflumic-acid ()
Acido niflumico ()
Acide niflumique ()
NSC-758196 ()
UP 83 ()
UP-83 ()
Niflugel ()
P&D ID
PD001431
CAS
4394-00-7
Tags
available
drug
Drug indication
Myalgia
Rheumatoid arthritis
Drug Status
approved
experimental
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Niflumic acid is used clinically as an anti-inflammatory agent due to its action as a cyclooxygenase-2 (COX-2) inhibitor.
(GtoPdb)
DESCRIPTION
Niflumic acid is a calcium-activated chloride channel blocker and COX-2 inhibitor with the IC50 value of 100 nM. Niflumic acid induces apoptosis through caspase-8/Bid/Bax pathway in lung cancer cells. Niflumic acide exhibits anti-tumor activity by affecting the expression of ERK1/2 and the activity of MMP2 and MMP9. Niflumic acid has orally bioactivity. Niflumic acid acts on rheumatoid arthritis[1][2][3][4][5][6][7][8].
PRICE
29
DESCRIPTION
Potent Rho-kinase inhibitor; vasodilator
(Tocris Bioactive Compound Library)
DESCRIPTION
Selective prostaglandin H synthase 2 (PGHS-2) inhibitor
(LOPAC library)
DESCRIPTION
Niflumic acid is a selective inhibitor of Prostaglandin G/H synthase 2. It is used to alleviate inflammation, pain, and edema associated with acute and chronic inflammatory conditions, such as rheumatoid arthritis, osteoarthritis, post-operative inflammatory conditions, and physical trauma.
(Enamine Bioactive Compounds)
DESCRIPTION
Niflumic acid (Nifluril) is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
29
Cayman Chemical Bioactives
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
JUMP-Target 1 Compound Set
Ki Database
LOPAC library
MedChem Express Bioactive Compound Library
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
35
Molecular Weight
282.06
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
3.54
TPSA
62.22
Fraction CSP3
0.08
Chiral centers
0.0
Largest ring
6.0
QED
0.9
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
COX-2
Primary Target
Cyclooxygenases
MOA
Inhibitor
cyclooxygenase inhibitor
Indication
joint pain, muscle pain
Disease Area
rheumatology, neurology/psychiatry
Target
ANO1, CLCN1, CLCNKA, CLCNKB, KCNQ1, PLA2G1B, PLA2G4A, PTGS1, PTGS2, UGT1A9
UGT1A9
Chloride channel
COX
COX,GABA Receptor
Chloride channel protein ClC-Ka
Monocarboxylate Transporter
PLA2
UGT
Pathway
Immunology/Inflammation
Membrane Transporter/Ion Channel
Metabolism
Neuroscience
Therapeutic Class
Antiinflammatory Agents
Source data
