General
Preferred name
NIFLUMIC ACID
Synonyms
Nifluril ()
Landruma ()
Forenol ()
niflumic-acid ()
UP 83 ()
UP-83 ()
NSC-758196 ()
Niflugel ()
P&D ID
PD001431
CAS
4394-00-7
Tags
natural product
drug
available
Drug indication
Rheumatoid arthritis
Drug Status
experimental
approved
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Niflumic acid is used clinically as an anti-inflammatory agent due to its action as a cyclooxygenase-2 (COX-2) inhibitor. (GtoPdb)
DESCRIPTION Selective prostaglandin H synthase 2 (PGHS-2) inhibitor (LOPAC library)
DESCRIPTION Potent Rho-kinase inhibitor; vasodilator (Tocris Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
27
Cayman Chemical Bioactives
70650
ChEMBL Drugs
CHEMBL63323
Concise Guide to Pharmacology 2017/18
2439
Concise Guide to Pharmacology 2019/20
2439
Concise Guide to Pharmacology 2021/22
2439
Concise Guide to Pharmacology 2023/24
2439
Drug Repurposing Hub
DrugBank
DB04552
DrugCentral
1925
DrugCentral Approved Drugs
1925
DrugMAP
DMJ3I1Q
DrugMAP Approved Drugs
DMJ3I1Q
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100592
Guide to Pharmacology
2439
JUMP-Target 1 Compound Set
4488
Ki Database
Niflumic acid
LOPAC library
MedChem Express Bioactive Compound Library
HY-B0493
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
niflumic-acid
TargetMol Bioactive Compound Library
T0693
The Spectrum Collection
Tocris Bioactive Compound Library
4112
External IDs
33
Properties
(calculated by RDKit )
Molecular Weight
282.06
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
3.54
TPSA
62.22
Fraction CSP3
0.08
Chiral centers
0.0
Largest ring
6.0
QED
0.9
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
COX-2
Pathway
Immunology/Inflammation
Membrane Transporter/Ion Channel
Metabolism
Neuroscience
Target
COX
Monocarboxylate Transporter
Chloride channel protein ClC-Ka
PLA2
UGT
ANO1, CLCN1, CLCNKA, CLCNKB, KCNQ1, PLA2G1B, PLA2G4A, PTGS1, PTGS2, UGT1A9
UGT1A9
Chloride channel
COX,GABA Receptor
Primary Target
Cyclooxygenases
MOA
Inhibitor
cyclooxygenase inhibitor
Indication
joint pain, muscle pain
Disease Area
rheumatology, neurology/psychiatry
Therapeutic Class
Antiinflammatory Agents
Source data