General
Preferred name
tretinoin
Synonyms
ATRA ()
all-trans-Retinoic acid ()
Retinoic acid ()
NSC122758 ()
Vitamin A acid ()
Retinoic acid ()
Accutane ()
isotretinoin ()
trans-Retinoic acid302-79-4 ()
Retinoic acid, All-trans Retinoic Acid, ATRA, Vitamin A acid, Vesanoid, Airol, Renova, Atralin, Retin-A, Avita, Stieva-A,NSC 122758 ()
All trans retinoic acid ()
Tretinoin (NSC 122758) ()
TretinoinVesanoidATRAall trans-Retinoic acidRetinoic acidVitamin A acidRetin-ATretinoin, all-trans-all-trans-Retinoic acidall-trans-Vitamin A acid ()
all-trans Retinoic Acid ()
Tretinoine ()
Aberel ()
Tretinoina ()
Tretinoin component of tri-luma ()
Vesanoid ()
Tretinoin component of solage ()
Altreno ()
Retin-a-micro ()
Tretinoin component of veltin ()
Oristar rna ()
Atralin ()
Avita ()
Eudyna ()
Tretin-X ()
Retin-A Micro ()
NSC-122758 ()
Retin a ()
Kerlocal ()
Tretinoin component of ziana ()
Renova ()
Retin-A ()
Tretinoin component of twyneo ()
Acticin ()
all-trans Retinoic Acid-d5 ()
P&D ID
PD001430
CAS
302-79-4
187175-63-9
4759-48-2
124510-04-9
Tags
available
drug
probe
Approved by
FDA
First approval
1971
Drug indication
acne
Acne vulgaris
Acute promyelocytic leukaemia
Drug Status
approved
investigational
nutraceutical
Max Phase
4.0
Probe info
Probe type
calculated probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
2
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Tretinoin is a naturally occurring derivative of vitamin A (retinoic acid) and as such is an agonist at the retinoic acid receptors. Tretinoin binds to α, β, and γ isoforms of the retinoic acid receptor. Retionoids are important regulators of cell reproduction, proliferation, and differentiation.
(GtoPdb)
DESCRIPTION
Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RAR¦Á/¦Â/¦Ã. Retinoic acid bind to PPAR¦Â/¦Ä with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.
PRICE
29
DESCRIPTION
Retinoic acid (Tretinoin), a metabolite of vitamin A, is a natural agonist of the retinoic acid receptor RAR and inhibits RAR??/??/?? (IC50=14 nM). Retinoic acid induces cellular differentiation, reduces cellular proliferation, and inhibits tumorigenesis.
DESCRIPTION
Retinoic acid analog; RARalpha agonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Induces caspase-dependent apoptosis
(LOPAC library)
DESCRIPTION
Endogenous retinoic acid receptor agonist.
(Tocriscreen Total)
DESCRIPTION
Retinoic acid (Tretinoin), a metabolite of vitamin A, is a natural agonist of the retinoic acid receptor RAR and inhibits RARα/β/γ (IC50=14 nM). Retinoic acid induces cellular differentiation, reduces cellular proliferation, and inhibits tumorigenesis.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
211
Organisms
3
Compound Sets
41
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
Bioprocess diversity set
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Natural product-based probes and drugs
NIH Approved Oncology Drugs
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
NURSA ligand set
Prestwick Chemical Library
Probe Miner (suitable probes)
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
Tocriscreen Total
Welcome Trust Cancer Drugs
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
93
Molecular Weight
300.21
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
1
Aromatic Ring Count
0
cLogP
5.6
TPSA
37.3
Fraction CSP3
0.45
Chiral centers
0.0
Largest ring
6.0
QED
0.53
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Target
Retinoic acid and retinoid X receptor agonist
ALDH1A1, ALDH1A2, GPRC5A, NR0B1, NR2C2, PPARD, RARA, RARB, RARG, RARRES1, RORB, RORC, RXRB, RXRG
RAR ligand
Endogenous Metabolite
Organoid
PPAR
RAR/RXR
Retinoid Receptor
RAR
Biological process
Vesicle traffic
Pathway
Autophagy
DNA Damage/DNA Repair
Metabolism
Cell Cycle/DNA Damage
Metabolic Enzyme/Protease
Stem Cell/Wnt
Vitamin D Related/Nuclear Receptor
Primary Target
Retinoic Acid Receptors
MOA
Agonist
Retinoid RORbeta Ligands
retinoid receptor agonist, retinoid receptor ligand
Member status
virtual
Indication
acute promyelocytic leukemia (APL)
Biosynthetic Origin
Terpenoid
Therapeutic Indication
Antiacne
Therapeutic Class
Keratolytic Agents
Source data
