General
Preferred name
LIOTHYRONINE SODIUM
Synonyms
LIOTHYRONINE (L- isomer) SODIUM ()
3,3',5-Triiodo-L-thyronine sodium ()
Triostat ()
T3 Sodium salt ()
Sodium L-3,3',5-triiodothyronine ()
Cytomel ()
Liothyronine (sodium) ()
Triiodothyronine (sodium) ()
3,3',5-Triiodo-L-thyronine (sodium) ()
T3 (sodium) ()
L-triiodothyronine sodium salt ()
Cynomel ()
L-triiodothyronine hydrochloride ()
Triiodothyronine ()
Ibiothyron ()
NSC-80774 ()
Thybon ()
Triiodothyronine,evans ()
Liothyronine sodium salt ()
Lyothyronin ()
Liotrix (t3) ()
Basoprocin ()
Triiodothyronine sodium salt ()
NSC-758175 ()
T3 (liotrix) ()
Rathyronine sodium, (s)- ()
Tertroxin ()
Rathyronine hydrochloride, (s)- ()
Cytobin ()
Liothyronine hydrochloride ()
P&D ID
PD001406
CAS
55-06-1
6893-02-3
Tags
available
drug
Drug Status
approved
Max Phase
4.0
Drug indication
congenital heart disease
First approval
1956
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
55
DESCRIPTION
Liothyronine Sodium is the sodium salt form of liothyronine, a synthetic form of the levorotatory isomer of the naturally occurring thyroid hormone triiodothyronine (T3). Liothyronine sodium (3,3',5-Triiodo-L-thyronine sodium) binds to nuclear thyroid receptors which then bind to thyroid hormone response elements of target genes. As a result, liothyronine sodium induces gene expression that is required for normal growth and development. Liothyronine sodium is more potent and has a more rapid action than thyroxine (T4).
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
8
ChEMBL Approved Drugs
ChEMBL Drugs
EU-OPENSCREEN Bioactive Compound Library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
21
Molecular Weight
672.77
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
2
cLogP
-0.38
TPSA
95.61
Fraction CSP3
0.13
Chiral centers
1.0
Largest ring
6.0
QED
0.33
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
THR
TRα
TRβ
Endogenous Metabolite
Thyroid hormone receptor
Pathway
Endocrinology/Hormones
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Source data
