General
Preferred name
CISPLATIN
Synonyms
CDDP ()
cis-Diammineplatinum(II) dichloride ()
cis-Diaminodichloroplatinum ()
Cisplatinum ()
Lederplatin ()
Briplatin ()
Cismaplat ()
trans-Platinum(II)diammine dichloride ()
trans-platinumdiamminedichloride ()
P&D ID
PD001382
CAS
14283-03-5
15663-27-1
14913-33-8
Tags
available
drug
inorganic
contains metal
Drug indication
Solid tumour/cancer
Osteosarcoma
Drug Status
approved
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Cisplatin is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. It is used for the treatment of metastatic testicular tumors, metastatic ovarian tumors and advanced bladder cancer. (Enamine Bioactive Compounds)
DESCRIPTION Antitumor antibiotic agent. Inhibits DNA topoisomerase II (Tocris Bioactive Compound Library)
Compound Sets
10
CZ-OPENSCREEN Bioactive Library
DrugMAP
DMRHGI9
DrugMAP Approved Drugs
DMRHGI9
DrugMatrix
Enamine Bioactive Compounds
EBC-17049
LINCS compound set
10245-101
MedChem Express Bioactive Compound Library
HY-W075885
The Spectrum Collection
Tocris Bioactive Compound Library
2251
Welcome Trust Cancer Drugs
1005
External IDs
54
Properties
(calculated by RDKit )
Molecular Weight
298.96
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
0
Ring Count
0
Aromatic Ring Count
0
cLogP
1.7
TPSA
70.0
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
0.0
QED
0.71
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
DNA replication
Cell Cycle/DNA Damage
Target
DNA crosslinker
DNA alkylator/crosslinker
Primary Target
Caspases
MOA
Activator
DNA/RNA Synthesis
Therapeutic Class
Anticancer Agents
Source data