General
Preferred name
CYCLOHEXIMIDE
Synonyms
Cicloheximide ()
Actidione ()
Naramycin A ()
CHX ()
Cycloheximide ()
NSC-185 ()
U-4527 ()
GNF-Pf-5118 ()
Cicloheximida ()
TCMDC-125838 ()
NSC-171 ()
P&D ID
PD001378
CAS
66-81-9
1154-57-0
Tags
available
drug candidate
nuisance
Drug indication
Discovery agent
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Cycloheximide is an antifungal antibiotic. It is known to inhibit the FKBP prolyl isomerase 1A (a.k.a. FKBP12) . (GtoPdb)
PRICE 29
DESCRIPTION Antifibrotic agent; regulates cytokine levels in vivo (Tocris Bioactive Compound Library)
DESCRIPTION Cycloheximide (Naramycin A) is a natural product that reversibly inhibits translation elongation, is an antimitotic compound, and is an inhibitor of DNA and protein synthesis. (TargetMol Bioactive Compound Library)
Cell lines
23
Organisms
11
Compound Sets
19
A Collection of Useful Nuisance Compounds (CONS) for Interrogation of Bioassay Integrity
AdooQ Bioactive Compound Library
A10036
Cayman Chemical Bioactives
14126
ChEMBL Drugs
CHEMBL123292
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
DMGDA3C
EU-OPENSCREEN Bioactive Compound Library
EOS101804
Guide to Pharmacology
5433
JUMP-Target 1 Compound Set
6197
LINCS compound set
10484-999
Novartis Chemogenetic Library (NIBR MoA Box)
Nuisance compounds in cellular assays
Prestwick Chemical Library
Reference compounds for characterizing cellular injury in high-content cellular morphology assays
ReFrame library
TargetMol Bioactive Compound Library
T1225
The Spectrum Collection
Tocris Bioactive Compound Library
0970
External IDs
41
Properties
(calculated by RDKit )
Molecular Weight
281.16
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
0
cLogP
1.04
TPSA
83.47
Fraction CSP3
0.8
Chiral centers
4.0
Largest ring
6.0
QED
0.76
Structural alerts
1
Protein disruption
Translation inhibition
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Pathway
Apoptosis
Autophagy
Cell Cycle/Checkpoint
DNA Damage/DNA Repair
Microbiology/virology
Primary Target
DNA, RNA and Protein Synthesis
MOA
Inhibitor
Translation inhibitor
Glycogen Synthase Kinase 3 beta (GSK-3beta
tau Protein Kinase I) Inhibitors
"Translation inhibitor
tau Protein Kinase I) Inhibitors"
protein synthesis inhibitor
Member status
member
Target
RPL3
DNA/RNA Synthesis
Fungal
Ferroptosis
antibiotic
Cellular injury category
Miscellaneous
Nuisance MOA
Protein disruption
Targets
Protein synthesis inhibitor Inhibit ferroptosis
Source data