General
Preferred name
CYCLOLEUCINE
Synonyms
P&D ID
PD001374
CAS
15313-85-6
52-52-8
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Cycloleucine is an antagonist of NMDA receptor associated glycine receptor with a Ki of 600 ??M. Cycloleucine is also a competitive inhibitor of S-adenosyl-methionine mediated methylation with anxiolytic and cytostatic effects.
DESCRIPTION Cycloleucine is non-metabolisable amino acid formed by cyclization of leucine. Cycloleucine is an antagonist of NMDA receptor, with Kd = 0.129 μM for NMDA 2D. It has cytostatic, immunosuppressive and antineoplastic activities. (Enamine Bioactive Compounds)
DESCRIPTION Cycloleucine is an antagonist of NMDA receptor associated glycine receptor with a Ki of 600 μM. Cycloleucine is also a competitive inhibitor of S-adenosyl-methionine mediated methylation with anxiolytic and cytostatic effects. (TargetMol Bioactive Compound Library)
Compound Sets
8
DrugBank
DB04620
DrugMAP
DM0L6E1
DrugMatrix
Enamine Bioactive Compounds
EBC-47318
MedChem Express Bioactive Compound Library
HY-30008
NIH Mechanistic Set
TargetMol Bioactive Compound Library
T9626
The Spectrum Collection
External IDs
32
Properties
(calculated by RDKit )
Molecular Weight
129.08
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
0
cLogP
0.34
TPSA
63.32
Fraction CSP3
0.83
Chiral centers
0.0
Largest ring
5.0
QED
0.54
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
NMDA Receptor
iGluR
Pathway
Neuroscience
Membrane Transporter/Ion Channel
Neuronal Signaling
Source data