General
Preferred name
ACPC
Synonyms
AMINOCYCLOPROPANECARBOXYLIC ACID ()
1-Aminocyclopropanecarboxylic acid hydrochloride ()
1-Aminocyclopropanecarboxylic Acid ()
1-Amino-1-carboxycyclopropane ()
ACC ()
1-Aminocyclopropane-1-carboxylic acid ()
1-Aminocyclopropane carboxylic acid ()
P&D ID
PD001372
CAS
68781-13-5
22059-21-8
Tags
available
drug candidate
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION 1-Aminocyclopropane-1-carboxylic acid (ACC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from seed germination to organ senescence. It is a small molecule agonist at the glycine modulatory site of the NMDA receptor (EC50 = 0.7-0.9 ??M) in the presence of low levels (1 ??M) of glutamate and as a competitive antagonist at the glutamate-binding site on NMDA receptors (EC50 = 81.6 nM) with high levels (10 ??M) of glutamate.2 This compound has been reported to protect against neuron cell death in vivo models of ischemia by enabling moderate levels of NMDA receptor activation and attenuating any excess NMDA receptor signaling that may lead to neurotoxicity.
DESCRIPTION 1-Aminocyclopropanecarboxylic acid is an inhibitor of Glutamate receptor ionotropic, NMDA 2D. (Enamine Bioactive Compounds)
DESCRIPTION 1-Aminocyclopropane-1-carboxylic acid (ACC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from seed germination to organ senescence. It is a small molecule agonist at the glycine modulatory site of the NMDA receptor (EC50 = 0.7-0.9 μM) in the presence of low levels (1 μM) of glutamate and as a competitive antagonist at the glutamate-binding site on NMDA receptors (EC50 = 81.6 nM) with high levels (10 μM) of glutamate.2 This compound has been reported to protect against neuron cell death in vivo models of ischemia by enabling moderate levels of NMDA receptor activation and attenuating any excess NMDA receptor signaling that may lead to neurotoxicity. (TargetMol Bioactive Compound Library)
DESCRIPTION NMDA glutamate receptor agonist acting at the glycine site (LOPAC library)
Cell lines
0
Organisms
1
Compound Sets
12
Cayman Chemical Bioactives
16132
Drug Repurposing Hub
DrugBank
DB02085
DrugMatrix
Enamine Bioactive Compounds
EBC-04372
Enamine BioReference Compounds
LOPAC library
MedChem Express Bioactive Compound Library
HY-30004
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
T4752
The Spectrum Collection
External IDs
58
Properties
(calculated by RDKit )
Molecular Weight
101.05
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
0
cLogP
-0.44
TPSA
63.32
Fraction CSP3
0.75
Chiral centers
0.0
Largest ring
3.0
QED
0.47
QED
0.47
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
NMDA-Glycine
Target
Endogenous Metabolite
NMDA Receptor
MOA
NMDAR
glutamate receptor antagonist
Pathway
Metabolism
Neuroscience
Metabolic Enzyme/Protease
Source data