General
Preferred name
ETHOSUXIMIDE
Synonyms
Etosuximida ()
Zarontin ()
Ethosuximidum ()
CN-10395 ()
NSC-64013 ()
CN-10,395 ()
Suxinutin ()
Emeside ()
CI-366 ()
PM-671 ()
Pyknolepsinum ()
Ethosuximide-d5 ()
P&D ID
PD001366
CAS
77-67-8
1989660-59-4
Tags
available
drug
Approved by
FDA
First approval
1960
Drug indication
Epilepsy
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Ethosuximide is a succinimide anticonvulsant. It is often preferred over as it does not produce the same hepatotoxicity.
(GtoPdb)
DESCRIPTION
Ethosuximide, a widely prescribed anti-epileptic agent, improves the phenotypes of multiple neurodegenerative disease models and blocks the low voltage activated T-type calcium channel.
PRICE
29
DESCRIPTION
Inhibits voltage-gated sodium channels; used for the treatment of absence-type seizures
(LOPAC library)
DESCRIPTION
Ethosuximide is a Calcium channel antagonist originated by Pfizer. It can be used for the treatment of Absence epilepsy and absence seizures. It may be used by itself or with other antiseizure medications such as valproic acid.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Ethosuximide is an anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures. It is a potent and selective T-type calcium channel modulator.
(Enamine Bioactive Compounds)
DESCRIPTION
Ethosuximide (Zarontin) is an anticonvulsant, blocks the low voltage-activated T-type calcium channel used in the treatment of absence seizures unaccompanied by other types of seizures.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
25
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
Ki Database
LOPAC library
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
40
Molecular Weight
141.08
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
0
cLogP
0.45
TPSA
46.17
Fraction CSP3
0.71
Chiral centers
1.0
Largest ring
5.0
QED
0.54
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Calcium Channel
Therapeutic Class
Analgesics
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Metabolism
Solubility
Chloroform, Ethyl Aceatae, Methanol
Source data
