General
Preferred name
ETHOSUXIMIDE
Synonyms
Etosuximida ()
Zarontin ()
Emeside ()
Pyknolepsinum ()
Ethosuximidum ()
NSC-64013 ()
CN-10395 ()
PM-671 ()
Suxinutin ()
CI-366 ()
CN-10,395 ()
Ethosuximide-d5 ()
P&D ID
PD001366
CAS
77-67-8
1989660-59-4
Tags
available
drug
Approved by
FDA
First approval
1960
Drug indication
Anticonvulsant
Epilepsy
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Ethosuximide is a succinimide anticonvulsant. It is often preferred over as it does not produce the same hepatotoxicity. (GtoPdb)
DESCRIPTION Inhibits voltage-gated sodium channels; used for the treatment of absence-type seizures (LOPAC library)
DESCRIPTION Ethosuximide is a Calcium channel antagonist originated by Pfizer. It can be used for the treatment of Absence epilepsy and absence seizures. It may be used by itself or with other antiseizure medications such as valproic acid. (BOC Sciences Bioactive Compounds)
Compound Sets
24
BOC Sciences Bioactive Compounds
ethosuximide-cas-77-67-8-item-476616
Cayman Chemical Bioactives
23947
30759
ChEMBL Approved Drugs
CHEMBL696
ChEMBL Drugs
CHEMBL696
CZ-OPENSCREEN Bioactive Library
DrugBank
DB00593
DrugBank Approved Drugs
DB00593
DrugCentral
1087
DrugCentral Approved Drugs
1087
DrugMAP
DMDZ9LT
DrugMAP Approved Drugs
DMDZ9LT
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
7182
Ki Database
Ethosuximide
LOPAC library
MedChem Express Bioactive Compound Library
HY-B1378
NCATS Inxight Approved Drugs
5SEH9X1D1D
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
ethosuximide
TargetMol Bioactive Compound Library
T0728
The Spectrum Collection
External IDs
40
Properties
(calculated by RDKit )
Molecular Weight
141.08
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
0
cLogP
0.45
TPSA
46.17
Fraction CSP3
0.71
Chiral centers
1.0
Largest ring
5.0
QED
0.54
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Target
Calcium Channel
Therapeutic Class
Analgesics
Solubility
Chloroform, Ethyl Aceatae, Methanol
Source data