General
Preferred name
RESVERATROL
Synonyms
ML027 Analog ()
trans-Resveratrol ()
SRT 501 ()
Resveratrol (Standard) ()
resveratrol, Royalmount ()
SRT501 ()
trans-Resveratrol (Standard) ()
SRT501 (Standard) ()
Resveratrol (SRT501) ()
trans-Resveratrol,SRT501 ()
3,5,4'-Trihydroxy-trans-stilbene ()
BIA-6-512 ()
Ca 1201 ()
Biofort ()
NSC-327430 ()
Cuspidatin ()
BIA 6-512 ()
Resvida ()
Resveratrol(e)-form ()
(E)-resveratrol ()
Srt 501m ()
Melinjo resveratrol 20 ()
Polygonin ()
(e)-5-(p-hydroxystyryl)resorcinol ()
Resveratrol p 5 ()
trans-Resveratrol-d4 ()
P&D ID
PD001353
CAS
501-36-0
31100-06-8
1089051-56-8
Tags
available
obsolete probe
nuisance
probe
natural product
drug candidate
Drug indication
Giant cell arteritis
Rheumatoid arthritis
Colorectal cancer
Systemic sclerosis
Drug Status
investigational
Max Phase
Phase 3
Probe info
Probe selectivity
protein-selective
Probe type
calculated probe
Probe sources
Probe Miner (suitable probes)
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Resveratrol is a natural product found in the skins of grapes and some other berries used predominantly as an antioxidant dietery supplement . The compound exists as a mixture of trans- (shown here) and cis- (PubChem CID 1548910) conformations. Resveratrol has been investigated for its various roles in complex biological processes . It has some activity as a cyclooxygenase inhibitor/antiinflammatory agent. (GtoPdb)
DESCRIPTION Cyclooxygenase-2 (COX-2) inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION Prevents apoptosis in K562 cells by inhibiting lipoxygenase and cyclooxygenase activity (LOPAC library)
DESCRIPTION Cyclooxygenase inhibitor (Tocriscreen Total)
DESCRIPTION Cyclooxygenase inhibitor (Tocriscreen Plus)
Cell lines
45
Organisms
4
Compound Sets
26
AdooQ Bioactive Compound Library
A10785
Cayman Chemical Bioactives
70675
13130
ChEMBL Drugs
CHEMBL165
Concise Guide to Pharmacology 2023/24
8741
Drug Repurposing Hub
DrugBank
DB02709
DrugMAP
DM3RWXL
Guide to Pharmacology
8741
LINCS compound set
10318-101
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL165
MedChem Express Bioactive Compound Library
HY-16561
HY-16561R
MLSMR Probes +
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
Nuisance compounds in cellular assays
Obsolete Compounds
resveratrol
Probe Miner (suitable probes)
P27487/96102
ReFrame library
Selleckchem Bioactive Compound Library
Resveratrol
TargetMol Bioactive Compound Library
T1558
The Spectrum Collection
Tocris Bioactive Compound Library
1418
Tocriscreen Plus
1418
Tocriscreen Total
ZINC Tool Compounds
ZINC000000006787
External IDs
55
Properties
(calculated by RDKit )
Molecular Weight
228.08
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
2
cLogP
2.97
TPSA
60.69
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.69
Structural alerts
2
historic compounds (Chemical Probes.org)
Obsolete
Nonspecific/NOS
Resveratrols
Nuisance compounds in cellular assays
Related compounds
Custom attributes
(extracted from source data)
Classification
probe analog
Target Type
Enzymes
Selectivity
COX
Pathway
NF-¦ÊB
Chromatin/Epigenetic
Immunology/Inflammation
DNA Damage/DNA Repair
Metabolism
NF-??b
Neuroscience
NF-??
Anti-infection
Apoptosis
Autophagy
Cell Cycle/DNA Damage
Epigenetics
NF-κB
Target
COX-1
COX-2
DNA polymerase ??
IKK??
LOX
Quinone reductase 2
SIRT1
SIRT2
CSNK2A1, NQO2, PTGS1, PTGS2
antibiotic
Bacterial
Fungal
IKK
Keap1-Nrf2
Mitophagy
AMPK,Apoptosis related,Autophagy,COX,ERK,I¦ÊB/IKK,JNK,Lipoxygenase,Mitophagy,Sirtuin,Src,STAT
Primary Target
Cyclooxygenases
MOA
DNA/RNA Synthesis
I¦ÊB/IKK
Lipoxygenase
NADPH
Sirtuin
Inhibitor
Anti-inflammatory
Antioxidant
cytochrome P450 inhibitor, SIRT activator
Member status
member
Source data