General
Preferred name
CAMPTOTHECIN
Synonyms
(S)-(+)-Camptothecin ()
CPT ()
Campathecin ()
NSC-100880 ()
Camptothecine (S,+) ()
Camptothecine ()
Compound010 ()
camptothecin prodrug, Mersana ()
CPT, Campathecin, (S)-(+)-Camptothecin ()
Camptothecin (NSC-100880) ()
Topotecan related compound c ()
NSC-94600 ()
P&D ID
PD001348
CAS
7689-03-4
31456-25-4
72517-83-0
Tags
available
drug candidate
nuisance
Drug indication
Solid tumour/cancer
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA
Camptothecin binds to the topoisomerase I and DNA complex resulting in a ternary complex, stabilizing it and preventing DNA re-ligation and therefore causes DNA damage which results in apoptosis.
TOXICITY
Acute oral toxicity (LD50) in mouse: 50.1 mg/kg;
PRICE
29
DESCRIPTION
Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM[1]. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1¦Á (HIF-1¦Á) activity by changing microRNAs (miRNA) expression patterns in human cancer cells[2][3].
DESCRIPTION
Calcineurin inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
DNA topoisomerase I inhibitor
(LOPAC library)
DESCRIPTION
DNA topoisomerase inhibitor
(Tocriscreen Total)
DESCRIPTION
Camptothecin is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. Camptothecin binds to the topoisomerase I and DNA complex resulting in a ternary complex, stabilizing it and preventing DNA re-ligation and therefore causes DNA damage which results in apoptosis.
(Enamine Bioactive Compounds)
DESCRIPTION
Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity. Camptothecin has antitumor activity and induces apoptosis.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
668
Organisms
4
Compound Sets
24
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugMAP
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
LOPAC library
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Nuisance compounds in cellular assays
Prestwick Chemical Library
Reference compounds for characterizing cellular injury in high-content cellular morphology assays
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
Tocriscreen Total
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
43
Molecular Weight
348.11
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
5
Aromatic Ring Count
3
cLogP
2.08
TPSA
81.42
Fraction CSP3
0.25
Chiral centers
1.0
Largest ring
6.0
QED
0.53
Structural alerts
1
Intercalation
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Selectivity
TopoI
Pathway
Antibody-drug Conjugate/ADC Related
Apoptosis
Chromatin/Epigenetic
DNA Damage/DNA Repair
Microbiology/virology
Anti-infection
Cell Cycle/DNA Damage
Epigenetics
Primary Target
DNA Topoisomerases
MOA
Inhibitor
topoisomerase I
Topoisomerase inhibitor
Member status
member
Target
TOP1
ADC Payload
antibiotic
Fungal
Influenza Virus
MicroRNA
Topoisomerase
ADC Cytotoxin,Apoptosis related,MicroRNA,Topoisomerase
ADC Cytotoxin
Topo I
Cellular injury category
Genotoxin
Source data
