General
Preferred name
CANDESARTAN
Synonyms
CV-11974 D4 ()
Candesartan D4 ()
CV 11974 ()
Candesartan (Atacand) ()
2-ethoxy-1-{[2'-(1H-1,2,3,4-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl}-1H-1,3-benzodiazole-7-carboxylic acid ()
CV-11974 ()
Candesartan (CV-11974) ()
[3H]candesartan ()
NSC-759858 ()
CANDESARTAN CILEXETIL RELATED COMPOUND G ()
CANDEMORE ()
BLOPRESS ()
Candesartan ()
Candesartan-d4 ()
P&D ID
PD001315
CAS
139481-59-7
1346604-70-3
Tags
available
drug
Drug indication
Hypertension
Cardiovascular disease
Drug Status
approved
experimental
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION The position of the tritiated hydrogen atom is unspecified by the reference describing this compound and so the radiolabel is not shown in this structure. (GtoPdb)
DESCRIPTION Candesartan (CV 11974) is an orally active angiotensin II AT1-Receptor blocker and PPAR-¦Ã agonist. Candesartan has potent and long-lasting antihypertensive effects. Candesartan can be used for the research of hypertension, chronic heart failure (CHF) and Traumatic brain injury (TBI)[1][2][3].
PRICE 50
DESCRIPTION Prodrug of candesartan (Cat. No. 4791), an AT1 receptor antagonist (Tocris Bioactive Compound Library)
DESCRIPTION AT1 receptor antagonist (Tocriscreen Plus)
DESCRIPTION Candesartan is an inhibitor of the angiotensin II type 1 (AT1) receptor. It is used for the treatment of hypertension. (Enamine Bioactive Compounds)
DESCRIPTION Candesartan (CV 11974) is an angiotensin II receptor blocker widely used in the treatment of hypertension and heart failure. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
30
AdooQ Bioactive Compound Library
A10175
Cayman Chemical Bioactives
9003239
25419
ChEMBL Drugs
CHEMBL1016
Concise Guide to Pharmacology 2017/18
587
Concise Guide to Pharmacology 2019/20
587
6907
Concise Guide to Pharmacology 2021/22
587
6907
Concise Guide to Pharmacology 2023/24
587
6907
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB13919
DrugMAP
DMRK8OT
DrugMAP Approved Drugs
DMRK8OT
DrugMatrix
Enamine Bioactive Compounds
EBC-06094
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101078
EUbOPEN Chemogenomics Library
EUB0000863
Guide to Pharmacology
587
6907
Ki Database
CANDESARTAN
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1016
MedChem Express Bioactive Compound Library
HY-B0205
NCATS Inxight Approved Drugs
S8Q36MD2XX
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Candesartan(Atacand)
TargetMol Bioactive Compound Library
T1461
The Spectrum Collection
Tocris Bioactive Compound Library
4791
Tocriscreen Plus
4791
External IDs
48
Properties
(calculated by RDKit )
Molecular Weight
440.16
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
5
Aromatic Ring Count
5
cLogP
4.03
TPSA
118.81
Fraction CSP3
0.12
Chiral centers
0.0
Largest ring
6.0
QED
0.39
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Target
Angiotensin Receptor
AT1 receptor
AGTR1
PPAR
Pathway
GPCR/G protein
Cell Cycle/DNA Damage
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Endocrinology/Hormones
Primary Target
Angiotensin AT1 Receptors
MOA
Antagonist
angiotensin receptor antagonist
Indication
hypertension, congestive heart failure
Therapeutic Class
Antihypertensive Agents
Recommended Cell Concentration
100 nM
Source data