General
Preferred name
LOMUSTINE
Synonyms
CCNU ()
NSC 79037 ()
NSC79037 ()
Lomustine (CeeNU) ()
NSC79037, Gleostine, CeeNU, CCNU ()
LomustineCeeNUCCNUN-(2-Chloroethyl)-N'-cyclohexyl-N-nitrosoureaBelustine1-(2-Chloroethyl)-3-cyclohexylnitrosourea1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea1-Nitrosourea, 1-(2-chloroethyl)-3-cyclohexyl-Urea, 1-(2-chloroethyl)-3-cyclohexyl)-1-nitroso-SRI 2200 ()
CCN-U ()
Lomustina ()
NSC-79037 ()
Gleostine ()
CeeNU ()
P&D ID
PD001312
CAS
13010-47-4
Tags
available
drug
nuisance
Approved by
FDA
First approval
1976
Drug indication
Brain cancer
Neoplasm
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Lomustine (CCNU; NSC 79037) is a DNA alkylating agent, with antitumor activity.
PRICE 29
DESCRIPTION Lomustine is an antineoplastic DNA alkylating agent. (GtoPdb)
DESCRIPTION Lomustine (NSC-79037) is an alkylating agent of value against both hematologic malignancies and solid tumors. (TargetMol Bioactive Compound Library)
Compound Sets
21
AdooQ Bioactive Compound Library
A10535
Cayman Chemical Bioactives
21237
ChEMBL Approved Drugs
CHEMBL514
ChEMBL Drugs
CHEMBL514
DrugBank
DB01206
DrugBank Approved Drugs
DB01206
DrugCentral
1596
DrugCentral Approved Drugs
1596
DrugMAP
DMMWSUL
DrugMAP Approved Drugs
DMMWSUL
DrugMatrix
Guide to Pharmacology
7214
MedChem Express Bioactive Compound Library
HY-13669
NCATS Inxight Approved Drugs
7BRF0Z81KG
NIH Approved Oncology Drugs
119147
NPC Screening Collection
Nuisance compounds in cellular assays
ReFrame library
Selleckchem Bioactive Compound Library
Lomustine(CeeNU)
TargetMol Bioactive Compound Library
T1601
The Spectrum Collection
External IDs
36
Properties
(calculated by RDKit )
Molecular Weight
233.09
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
1
Aromatic Ring Count
0
cLogP
2.25
TPSA
61.77
Fraction CSP3
0.89
Chiral centers
0.0
Largest ring
6.0
QED
0.46
Structural alerts
1
Genotoxic
Nuisance compounds
Custom attributes
(extracted from source data)
Pathway
Apoptosis
Autophagy
DNA Damage/DNA Repair
Cell Cycle/DNA Damage
Target
DNA alkylator/crosslinker
DNA/RNA Synthesis
DNA Alkylating
Stathmin-4
Therapeutic Class
Anticancer Agents
Source data